贲门癌与幽门螺杆菌感染的相关性研究

Study on correlation between cardiac carcinoma and Helicobacter pyloriinfections

目的分析贲门癌发生与幽门螺杆菌感染的相关性,为临床提供依据。方法选取医院收治的120例贲门癌患者为研究对象,另选取100例行上消化道内镜检查的上消化道非肿瘤疾病的患者为对照组,通过上消化道内镜对贲门不同位点组织进行病理活检,检测幽门螺杆菌感染情况。结果慢性活动性胃炎患者幽门螺杆菌感染阳性率为55.26%,肠上皮化生患者为57.14%,腺上皮萎缩患者为58.82%,不典型增生患者为60.00%,均高于慢性浅表性胃炎患者(18.75%),比较差异有统计学意义(P<0.05);观察组患者幽门螺杆菌感染阳性率为65.0%,高于对照组(51.0%),两组差异有统计学意义(P<0.05);观察组患者贲门区12点位幽门螺杆菌感染阳性率为55.83%,分别高于3点位(35.0%)、6点位(34.17%)、9点位(31.67%),比较差异有统计学意义(P<0.05);对照组患者贲门区不同位点幽门螺杆菌感染阳性率比较差异无统计学意义。结论贲门癌及贲门区黏膜癌前病变的发生与幽门螺杆菌感染存在一定关系。

OBJECTIVE To analyze the relationship between the cardiac carcinoma and Helicobacter pylori infections so as to provide basis for the clinical treatment. METHODS A total of 120 cardiac carcinoma patients were selected as the research objects, and 100 cases of patients with the upper gastrointestinal non tumor diseases who received routine upper gastrointestinal endoscopy were selected as the control group, then the pathological biopsy was performed for the tissues of different cardiac sites through the upper gastrointestinal endoscopy, and the H. pylori infection was examined. RESULTS The positive rate of the H. pylori infections was 55.26% in the chronic active gastritis patients, 57.14% in the intestinal metaplasia patients, 58.82% in the glandular epithelium atrophy patients, and 60. 0% in the untypical hyperplasia patients, all higher than 18. 75% of the chronic superficial gastritis patients, the difference was statistically significant （P〈0. 05）. The positive rate of the H. pyloriinfections was 65.0% of the observation group, higher than 51.0% of the control group,the difference was statistically significant（P〈0.05）. The positive rate of H. pylori infection in the 12 point of cardiac regions was 55.83% of the observation group, respectively higher than 35.0% of the point 3 ,34.17% of the point 6, and 31.67 % of the point 9,the difference was statistically significant （P〈0.05）. The difference in the positive rate of the H. pylori infection between the various cardiac regions of the patients in the control group was not statistically significant. CONCLUSION There is certain correlation between the incidence of cardiac carcinoma and the mucosa precancerous lesions of cardiac regions and the H. pylori infections.