1Nourjah P,Ahmad SR,Karwoski C,et al.Estimates of acetami-nophen(Paracetomal)-associated overdoses in the United States[J].Pharmacoepidemiol Drug Saf,2006,15(6):398-405.
2Larson AM,Polson J,Fontana RJ,et al.Acetaminophen-induced acute liver failure:results of a United States multicenter,prospective study[J].Hepatology,2005,42(6):1364-1372.
4Macdonald TM.Acetaminophen:risk-management urgently requi-red[J].Pharmacoepidemiol Drug Saf,2006,15(6):406-409.
5Hawton K,Simkin S,Deeks J,et al.UK legislation on analgesicpacks:before and after study of long term effect on poisonings[J].BMJ,2004,329(7474):1076.
6CS Loh,罗敬秀,Ponampalam R.Nephrotoxicity associated withacute paracetamol overdose:a case report and review of the litera-ture[J].Hong Kong Journal of Emergency Medicine,2006,13(2):105-110.
7Vermeulen NPE,Bessems JGM,Van De Straat R.Molecularaspect of paracetamol-induced hepatotoxicity and its mechanismbased prevention[J].Drug Metab Rev,1992,24(3):367-407.
8Kramers C,Jansman F G,Droogleever FH.[A patient who re-fused treatment after self-poisoning with paracetamol[J].Ned Tijd-schr Geneeskd,2006,150(29):1601-1604.
9Kaushal R,Dave KR,Katyare SS.Paracetamol hepatotoxicityand microsomal function[J].Environmental Toxicology and Phar-macology,1999,7(1):67-74.
2STIPANUK MH. Sulfur amino acid metabolism:pathways for productionand removal of homocysteine and cysteine [ J ]. Annu Rev Nutr, 2004,24:539.
3TAKUSAGAWA F,OGAWA H,FUJIKOA M. Glycine N-methyhransferase,a tetrameric enzyme [ M ] . //CHENG X, BLUMENTAL R, eds. S-adenosylmethionine dependent methyhransferases:stmcture and functions. Singapore : WortdScientific Publishing, 1999:93.
4CLARKE S, BANFIELD K. S-adenosylmethionine-dependent methyltransferase [ M ]. //CARMEL R, JACOBSEN DW, eds. Homocysteine in health and disease. Cambridge UK: Cambridge University Press, 2001:63.
5SUZUKI N,WAGNER C. Purification and characterization of a folate binding protein from rat liver cytosol [ J ]. Arch Biochem Biophys, 1980,199:236.
6OU X, YANG H, RAMANI K, et al. Inhibition of human betaine homocysteine methylytransferase expression by S-adenosylmethionine and methyhhioadenosine [ J ].Biochem J,2007,401 : 87.
7BALAGHI M,HORNE DW,WAGNER C. Hepatic one-carbon metabolism in early folate deficiency in rats [ J ]. Biochem J, 1993,291 : 145.
8MATO JM, LU SC. Homocysteine : the bad thiol [J ]. HEPATOLOGY, 2005,41:976.
9CHEN Z, KARAPLIS AC, ACKERMAN SL, et al. Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition[ J ]. Hum Mol Genet,2001,10:433.
10WATANABE M, OSADA J, ARATANI Y, et al. Mice deficient in cystathionine beta-synthase:animal models for mild and severe homocyst (e) inemia[ J]. Proc Natl Acad Sci USA, 1995,92 : 1585.
