摘要
目的建立离子色谱法测定厄贝沙坦中氰化物的含量。方法采用IonPac AS7(250 mm×2 mm)离子交换色谱柱,淋洗液采用0.1 mol.L-1氢氧化钠和0.2 mol.L-1乙酸钠,流速为0.3 mL.min-1。结果氰根离子在0.008～0.12μg.mL-1线性关系良好(r2=0.999 7),检测限为0.002μg.mL-1。在所建立的色谱条件下,氰根离子与各常见阴离子之间的分离度良好。结论该方法简单快速,专属性强,结果准确,可用作厄贝沙坦中氰化物的含量的检测。
Objective To establish an ion chromatography method to determine cyanide in irbesartan. Methods Ionpac AS7 （250 mm×2 mm） ion exchange column was used to separate anions. The eluent used was 0.1 mol.L^-1 NaOH and 0.2 mol.L^-1 sodium acetate with a flow rate of 0.3 mL .min ^- 1. Results Cyanide and other common anions were well isolated. The calibration graph of cyanide was linear within 0.008 -- 0.12 μg.mL^ -1 （r^2 = 0.999 7）. The detection limit of cyanide was 0.002 μg .mL^ -1. Conclusion The method is simple, rapid, accurate and suitable for the determination of cyanide in irbesartan.
出处
《中南药学》
CAS
2013年第2期132-134,共3页
Central South Pharmacy
关键词
厄贝沙坦
氰化物
离子色谱
irbesartan
cyanide
ion chromatography
