皮肤组织晚期糖基化终产物对高血压患者血管弹性功能影响的研究

Effect of advanced glycation end products in skin tissue on vascular elasticity in hypertensive patients

目的探讨高血压患者皮肤组织晚期糖基化终产物(AGE)的变化特点及与血管弹性功能异常的相关性。方法选择高血压患者157例,依据合并疾病分为高血压组62例,高血压合并糖尿病组(合并1组)42例,高血压合并糖尿病及冠心病组(合并2组)53例,同期选择健康体检者32例作为对照组。采用荷兰DiagnOptics公司AGE无创测量装置测定皮肤组织AGE水平,用皮肤自体荧光光谱(AF)值表示;采用法国Complior公司动脉弹性测定仪测定颈-股脉搏波传导速度(cf-PWV)。结果与对照组比较,高血压组、合并1组和合并2组的皮肤AF明显升高,差异有统计学意义(P<0.01);合并1组和合并2组cf-PWV明显升高(P<0.05,P<0.01)。与高血压组比较,合并1组和合并2组皮肤AF明显升高(P<0.01);合并2组cf-PWV明显升高,差异有统计学意义[(9.27±2.13)m/s vs(11.59±3.36)m/s,P<0.01]。AF与cf-PWV呈正相关(r=0.329,P=0.000)。结论高血压患者皮肤组织AGE水平增高对血管风险评价具有重要意义。

Objective To study the correlation between advanced glycation vascular elasticity in skin tissue of hypertensive hypertensive patients were divided into hyperten patients. Methods One end（AGE） prod hundred and fif ucts and ty-seven sion group（n= 62）, hypertension＋diabetes mellitus（DM） group（n=42） and hypertension＋DM＋coronary heart disease（CHD） group（n=53）. Thirty-two persons who underwent health check served as a control group. AGE products in their skin tissue expressed （cf-PWV） suits The group and were detected with an invasive detector from DiagnOptics Company of Netherlands and as auto-fluorescence（AF） spectrum value. Their carotid-femoral pulse wave velocity was measured with an artery elasticity analyzer from Complior Company of France. Results The AF spectrum value was significantly higher in hypertension group, hypertension＋DM hypertension＋DM＋CHD group than in control group（P〈0.01）. The cf-PWV was significantly higher in hypertension group than in hypertension＋ DM＋ CHD group[ （9.27 ＋ 2.13） m/s vs （11.59＋3.36）m/s,P〈0. 01]. The AF positively correlated with the cf-PWV（r=0. 329, P=0. 000） ,indicating that the AF sion The AGE products in skin t ment of vascular risks. spectrum value is an important factor for hypertension. Concluissue of hypertensive patients play an important role in assessment of vascular risks.