艾司西酞普兰与氟西汀治疗广泛性焦虑症的对照研究

Comparative Study of Escitalopram and Fluoxetine in the Treatment of General Anxiety Disorder(GAD)

目的探讨艾司西酞普兰与氟西汀治疗广泛性焦虑症(GAD)的疗效与安全性。方法采用随机分组的方法,将62例GAD患者随机分为艾司西酞普兰组(31例),氟西汀组(31例),治疗4周,在治疗前和治疗后1、2、4周分别进行汉密尔顿焦虑量表(HAMA)、副反应量表(TESS)评定疗效和不良反应。结果艾司西酞普兰组与氟西汀组对GAD均有显著疗效,两组间无显著性差异(χ2=0.198,P>0.05),艾司西酞普兰组不良反应明显小于氟西汀组(χ2=4.993,P<0.05)。结论艾司西酞普兰治疗GAD安全、有效,不良反应轻微,值得临床应用。

Objective To compare the efficacy and safety of escitalopram and fluoxetine in the treatment of GAD. Methods A total of 61 patients with GAD were randomly divided into escitalopram group （n=31）and fluoxetine group （n= 31）. They were treated for 4 weeks. The clinical efficacy and side effects were evaluated with HAMA and TESS before treatment and 1,2,4 weeks after treatment. Results There were significant efficacy and no significant difference in escitalopram group and fluoxetine group （X^2=0.198,P〉0. 05）. The side effects in escitalopram group were significantly lower than those in fluoxetine group （X^2= 4. 993,P d0.05）. Conclusion. Escitalopram shows efficacy and safety in the treatment of GAD with lower side effects.