度洛西丁对甲基苯丙胺依赖者情绪障碍的疗效观察

THE THERAPEUTIC EFFECT OF DULOXETINE ON EMOTIONAL DISORDERS INDUCED BY METHAMPHETAMINE WITHDRAWAL

目的:探讨度洛西丁对甲基苯丙胺依赖者情绪障碍的治疗效果。方法:对103例甲基苯丙胺依赖戒断者在成功脱瘾后的一周内,测查汉密顿焦虑量表(HAMA)、汉密顿抑郁量表(HAMD)。将103例患者随机分为对照组(n=51)和药物处理组(n=52),对照组仅给予简单的言语解释和支持,药物处理组给度洛西丁60 mg.d-1治疗。6周后复查HAMA和HAMD量表,评定治疗效果。结果:甲基苯丙胺依赖戒断者均有明显的焦虑、抑郁等情绪障碍。连续给予度洛西丁治疗6周后,HAMA、HAMD评分较对照组明显下降,有显著统计学差异(P<0.01)。结獉论獉:对甲基苯丙胺依赖戒断者脱瘾后早期使用度洛西丁干预,可缓解其情绪障碍,可能有利于防止复吸。

Objective：To investigate the therapeutic effect of Duloxetine on emotional disorders of patients with methamphetamine withdrawals. Methods：One hundred and three methamphetamine patients within one week after the withdrawal were measured with Hamilton Anxiety Scale （HAMA） and Hamilton ion Scale （HAMD）. One hundred and three patients were randomly divided into two groups, control group （n =51） and drug treatment group （n =52）. The control group was only given a simple verbal explanation and support, while the drug treatment group received Duloxetine treatment （60 mg . d- 1 ）. Six weeks later, all abstinents were reviewed by HAMA and HAMD again to assess the therapeutic effect. Results： Methamphetamine dependence withdrawal could induce anxiety, depression and other mood disorders. Treatment with Duloxetine for six weeks decreased HAMA, HAMD score significantly compared with the control group （P 〈 0. 01 ）. Conclusion： Treatment with Duloxetine in early stage of methamphetamine withdrawal could relief anxiety and depression - like symptoms, and is helpful to prevent relapse.