痛风、历节和行痹方剂组方规律的对比研究

A Comparative Study on Formula Composition Regularity for Gout,Severe Migratory Arthralgia and Migratory Arthralgia

目的对比分析古籍文献中治疗痛风、历节和行痹的处方用药及配伍规律。方法筛选古籍文献中治疗痛风、历节和行痹的方剂,根据方剂信息建立Access数据库,统计方剂中药物使用频率并应用假设检验与关联规则对前30味高频药物进行分析。结果共收集352首方剂,包括痛风78首、历节173首、行痹101首。3种方剂中均以当归为使用频率最高的药物,每种方剂中明显高于其他两类的高频药物是:痛风方剂中的苍术、黄柏和熟地黄,历节方剂中的麻黄和芍药,行痹方剂中的地龙。前30味高频药物主要分为补虚药、活血化瘀药、解表药、祛风湿药、利水化湿药、温里药、熄风通络药、清热药、其他,其中补虚药在痛风和历节中使用最多,活血化瘀药在行痹中使用最多。3种方剂支持度>10%、置信度>70%的药对共有11对。结论补虚、活血化瘀、解表和祛风湿药物在痛风、历节、行痹方剂中使用比例均较高,痛风和历节更注重补虚,行痹更注重活血化瘀,3种方剂用药相互交叉且有各自特点。

Objective To compare and analyze the formula composition regularity for gout, severe migratory arthralgia and migratory arthralgia in ancient literature. Methods The ancient formulas for gout, severe migratory arthralgia and migratory arthralgia were searched and the Access database was established according to the formula information. The top 30 high-fre- quency herbs were analyzed with hypothesis testing and association rules. Results Totally 352 formulas were collected inclu- ding 78 formulas for gout, 173 formulas for severe migratory arthralgia and 101 formulas for migratory arthralgia. Danggui （Radix Angelicae Sinensis） was the highest-frequency herb in three kinds of formulas. The frequently used herbs in each kind of formula as compared with other two kinds were： Cangzhu （Rhizoma Atractylodis）, Huangbai （Cortex Phellodendri Chinensis） and Shudihuang （Radix Rehmanniae Praeparata） in formulas for gout, Mahuang （Herba Ephedrae） and Shaoyao （Radix Paeoniae Alba） in formulas for severe migratory arthralgia, and Dilong （Pheretima） in formulas for migratory arthral- gia. The top 30 high-frequency herbs were tonic herbs, blood-quickening stasis-transforming herbs, exterior-resolving herbs, wind-damp-dispelling herbs, water-disinhibiting damp-transforming herbs, interior-warming herbs, wind-extinguishing net- work vessels freeing herbs and heat-clearing herbs. The frequently used herbs in formulas were tonic herbs for gout and severe migratory arthralgia and blood-quickening stasis-transforming herbs for migratory arthralgia. There were 11 couples of herbs with support above 10% and confidence above 70% in three kinds of formulas. Conclusion The frequently used herbs are ton- ic herbs, blood-quickening stasis-transforming herbs, exterior-resolving herbs and wind-damp-dispelling herbs in the formulas for gout, severe migratory arthralgia and migratory arthralgia. The formulas for gout and severe migratory arthralgia pay more attention to supplementing vacuity and the formulas for migratory arthralgia pay more attention to quickening the blood and transforming stasis. The three kinds of formulas cross each with own characteristics.