摘要
采用混酸、碱取代法合成3-氨基金刚烷醇。重点考察了投料比、反应温度、反应时间、催化剂影响因素。采用单因素试验,结果表明:(n)浓硫酸:(n)浓硝酸:(n)原料=40:2:1,(n)硝酸:(n)催化剂=1:2;硝化温度为20—30℃,碱化温度低于80℃;硝化时间10h,碱化时间1.5h;3-氨基金刚烷醇收率达到84%,含量97.66%。该方法操作简单,原料及试剂来源方便,价格便宜,目标产物收率较高,适合工业化生产。
The 3-aminoadamantanol was synthesised by mixed acids,and then was replaced by alkali. The materials ratio, reaction temperature,reaction time, catalyst were inspected. The results of single factor test show that: (n)concentrated sulfuric acid : (n)concentrated nitric acid : (n) amantadine hydrochloride= 40 : 2 : 1, (n)nitric acid : (n)catalyst= 1 : 2; nitration temperature is 20-30℃, alkalization temperature below 80℃ ; nitrification time 10h, alkalization time 1. 5h. The yield of 3-amino-adamantanol was 84%,contented of 97. 66%. The method has the advantages of simple operation, convenient source of raw materials and reagents, cost-effective and the high yield, which is suitable for industrialized production.
出处
《光谱实验室》
CAS
2013年第2期925-928,共4页
Chinese Journal of Spectroscopy Laboratory
基金
重庆市自然科学基金(CSTC
2006BB5286)
关键词
3-氨基金刚烷醇
混酸
单因素试验
优化
3-Aminoadamantanol
Mixed Acid
Single Factor Test
Optimization