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3-氨基金刚烷醇的合成工艺优化 被引量：7

Optimization of Synthetic Technological Conditions for 3-Aminoadamantanol
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摘要 采用混酸、碱取代法合成3-氨基金刚烷醇。重点考察了投料比、反应温度、反应时间、催化剂影响因素。采用单因素试验,结果表明:(n)浓硫酸:(n)浓硝酸:(n)原料=40:2:1,(n)硝酸:(n)催化剂=1:2;硝化温度为20—30℃,碱化温度低于80℃;硝化时间10h,碱化时间1.5h;3-氨基金刚烷醇收率达到84%,含量97.66%。该方法操作简单,原料及试剂来源方便,价格便宜,目标产物收率较高,适合工业化生产。 The 3-aminoadamantanol was synthesised by mixed acids,and then was replaced by alkali. The materials ratio, reaction temperature,reaction time, catalyst were inspected. The results of single factor test show that： （n）concentrated sulfuric acid ： （n）concentrated nitric acid ： （n） amantadine hydrochloride= 40 ： 2 ： 1, （n）nitric acid ： （n）catalyst= 1 ： 2; nitration temperature is 20-30℃, alkalization temperature below 80℃ ; nitrification time 10h, alkalization time 1. 5h. The yield of 3-amino-adamantanol was 84%,contented of 97. 66%. The method has the advantages of simple operation, convenient source of raw materials and reagents, cost-effective and the high yield, which is suitable for industrialized production.
作者 彭俊 冯悦 胡湘南
机构地区 重庆医科大学药学院
出处 《光谱实验室》 CAS 2013年第2期925-928,共4页 Chinese Journal of Spectroscopy Laboratory
基金 重庆市自然科学基金(CSTC 2006BB5286)
关键词 3-氨基金刚烷醇 混酸 单因素试验 优化 3-Aminoadamantanol Mixed Acid Single Factor Test Optimization
分类号 R914.5 [医药卫生—药物化学] O657.61 [理学—分析化学]
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参考文献9

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共引文献8

同被引文献31

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光谱实验室
2013年 第2期

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