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蓓萨罗丁的合成及优化

Synthesis and optimization of bexarotene
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摘要 以2,5-二甲基-2,5-己二醇为原料,经氯代、F-C烃化、F-C酰化、Wittig反应、水解反应等七步反应制得抗肿瘤药物蓓萨罗丁,并对其合成工艺进行优化,降低成本和操作难度,提高了产率。 The anti-cancer drug bexarotene was synthesized through seven main reactions such as chlorination,Friedel-Crafts alkyla- tion, Friedel-Crafts acylation,Wittig reaction, hydrolysis reaction etc. This route was optimized greatly which featured with low cost and easy operation procedure.
作者 魏玮 马帅 韩增影 曹胜华 丁小东
机构地区 中国医药集团总公司四川抗菌素工业研究所 四川大学分析测试中心
出处 《化学研究与应用》 CAS CSCD 北大核心 2013年第3期388-390,共3页 Chemical Research and Application
关键词 2 5-二甲基-2 5己二醇 蓓萨罗丁 工艺优化 2,5-dimethyl-2,5-hexanediol bexarotene process optimization
分类号 O625.5 [理学—有机化学]
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参考文献7

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共引文献6

化学研究与应用
2013年 第3期

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