含1,2,3-三唑环的α,γ-二酮衍生物的合成研究

Synthesis of α,γ-diketo derivatives containing 1,2,3-triazole ring

以对氯氯苄为原料,经取代、1,3-偶极环加成和缩合反应得到含1,2,3-三唑环的α,γ-二酮衍生物,其结构经1H NMR、13C NMR以及MS确证。研究表明,该α,γ-二酮化合物存在酮醇异构现象,在溶液中其酮醇异构体比例近似为1∶8。

α,γ--diketo derivatives containing 1,2,3-triasole ring were synthesized by replacement, 1,3-dipolar cycloaddition and condensation from p-chlorobenzyl chloride. The structure of the title compound was confirmed by l H NMR, 13 C NMR and MS. The results also indicated that keto-enol tautomerism of the α,γ--diketo derivatives was observed and the ratio of the keto-enol isomer ap- proximately was 1：81