短暂性脑缺血发作临床治疗分析

Analysis of clinical treatment for transient ischemic attack

目的研究分析短暂性脑缺血发作患者的临床治疗方法和治疗效果。方法回顾性分析2010年1月-2012年9月期间,我院收治的144例短暂性脑缺血发作患者的临床资料,根据采用治疗方法的不同,将患者随机分为两组,对照组72例,采用奥扎格雷钠(80mg)加入0.9%氯化钠溶液(100mL)静脉滴注治疗;观察组72例,采用奥扎格雷钠联合舒血宁静脉滴注治疗,每日1次,给药10天。比较两组患者治疗后的临床症状改善情况和治疗效果。结果治疗后观察组患者的治疗痊愈率和治疗总有效率分别为36.1%5、91.7%,对照组分别为27.8%、80.6%,与对照组比较差异明显,具有统计学意义(P<0.05);治疗后观察组患者的血液流变学指标和血脂指标均明显优于对照组,具有统计学意义(P<0.05)。结论奥扎格雷钠联合舒血宁静脉滴注治疗能够较好的降低患者的血液粘稠度、改善神经功能,是治疗短暂性脑缺血发作的良好方法,值得临床推广。

Objective To analyze the clinical treatment of transient ischemic attack （TIA） and its therapeutic effect. Methods A retrospective analysis was performed on the clinical data of 144 TIA patients who were admitted to our hospital from January 2010 to September 2012. The patients were randomly divided into control group （n = 72） who received sodium ozagrel （80 mg） in 0.9% sodium chloride solution （100 ml） by intravenous drip and observation group （n = 72） who received sodium ozagrel combined with Ginkgo biloba extract by intravenous drip once daily for 10 d. The two groups were compared in terms of improvement in symptoms and treatment outcome. Results The observation group had a cure rate of 36.1% and an overall response rate of 91.7%, versus 27.8% and 80.6% in the control group （P〈0.05）. The observation group showed better performances in hemorheological indices and blood lipid than the control group （P〈0.05）. Conclusion Intravenous drip of sodium ozagrel combined with Ginkgo biloba extract can decrease blood viscosity and improve neurological function in TIA patients. It is a desirable method for treating TIA and shows promise for clinical application.