摘要
Complexes of the type [Pt? (CH3NH2)(NH3){(OOC)2(CH2)n}] (Ⅰ～Ⅲ )(n=0,1,2) have been synthesized for the first time. At the same time, the three precursor complexes also have been synthesized. They were characterized by elemental analyses, molar conductance, differential thermal analyses and spectral (IR, UV, 1H NMR) studies. In vitro antitumor activity results indicated that these complexes have activity against HL 60 and U937, but show poor activity against K562.
Complexes of the type [Pt? (CH3NH2)(NH3){(OOC)2(CH2)n}] (Ⅰ～Ⅲ )(n=0,1,2) have been synthesized for the first time. At the same time, the three precursor complexes also have been synthesized. They were characterized by elemental analyses, molar conductance, differential thermal analyses and spectral (IR, UV, 1H NMR) studies. In vitro antitumor activity results indicated that these complexes have activity against HL 60 and U937, but show poor activity against K562.
出处
《无机化学学报》
SCIE
CAS
CSCD
北大核心
2000年第4期665-668,共4页
Chinese Journal of Inorganic Chemistry
基金
浙江省自然科学基金!( No.298068)
关键词
混胺铂配合物
合成
抗肿瘤活性
mixed amine platinum complexes synthesis antitumor activity
