环已二胺铂(Ⅱ)类配合物跨人红细胞膜动力学研究

The Kinetic Studies of Across-Erythrocyte Membrane Transport of 1,2 cyclohexanediamine Platinum(Ⅱ) Complexes

In the synthetic plasma, the uptake kinetics of sulfato 1,2 cyclohexanediamine platinum(Ⅱ) , selenato 1,2 cyclohexanediamine platinum(Ⅱ) , squarato 1,2 cyclohexanediamine platinum(Ⅱ) , demethylcantharato 1,2 cyclohexanediamine platinum(Ⅱ) , oxalato 1,2 cyclohexanediamine platinum(Ⅱ) , malonato 1,2 cyclohexanediamine platinum(Ⅱ) , butanedioicato 1,2 cyclohexanediamine platinum(Ⅱ) across human erythrocyte membrane transport have been studied. The experiment results showed that the across membrance transport of all the platinum? complexes followed a first order kinetic process. The rate constants of seven 1,2 cyclohexanediamine platinum? were determined. The uptake rates were related to the hydrolysis rate. The complexes of larger hydrolysis rate have the larger rate constant. The hydrolysis complexes with charge is considered to differ from the neutral complexes in the passages across erythrocyte membranes.