期刊文献+

膜-细胞骨架结合磷酸化蛋白50在子宫内膜癌中的表达及意义 被引量:1

下载PDF
导出
摘要 目的探讨膜-细胞骨架结合磷酸化蛋白50(ezrin-radixin-moesin-binding phosphoprotein 50,EBP50)在子宫内膜癌中的表达及临床意义。方法应用荧光定量PCR及免疫组化法检测EBP50在正常子宫内膜组织、子宫内膜不典型增生组织及子宫内膜癌组织中的表达情况。结果 EBP50 mRAN及蛋白在子宫内膜癌组织和子宫内膜不典型增生组织中的表达明显高于正常子宫内膜组织,三者差异均有统计学意义(P<0.05)。EBP50与子宫内膜癌的组织分级、肌层浸润深度、临床分期、淋巴结转移及雌激素受体有关(P<0.05)。结论EBP50与子宫内膜癌的发生发展、浸润及转移等恶性行为有关,检测EBP50的表达可能有助于子宫内膜癌的早期诊断及预后判断。
出处 《广东医学》 CAS CSCD 北大核心 2013年第3期404-406,共3页 Guangdong Medical Journal
基金 广西教育厅科研项目(编号:200911MS34) 广西研究生教育创新计划资助项目(编号:YCSZ2012042)
  • 相关文献

参考文献9

  • 1BARTHOLOW T L, BECICH M J, CHANDRAN U R, et al. Im- munohistochemical analysis of Ezrin - radixin - moesin - binding phosphoprotein 50 in prostatic adenocarcinoma [ J]. BMC Urol, 2011, 11: 12.
  • 2WEINMAN E J, STEPLOCK D, TATE K, et ah Structure - func- tion of recombinant NaYH exchanger regulatory factor ( NHE - RF) [J]. ClinInvest, 1998, 101(10): 2199 -2206.
  • 3MORALES F C, TAKAHASHI Y, MOMIN S, et al. NHERF1/ EBP50 head - to - tail intramolecular interaction masks association with PDZ domain ligands [ J ]. Mol Cell Biol, 2007, 27 (7) : 2527 - 2537.
  • 4BELLIZZI A, MALFETI'ONE A, CARDONE R A, et al. NHERF1/EBP50 in Breast Cancer: Clinical Perspectives [ J ]. Breast Care (Basel) , 2010, 5 (2) : 86 - 90.
  • 5SHIBATA T, CHUMA M, KOKUBU A, et al. EBP50, a beta - catenin - associating protein, enhances Wnt signaling and is over - expressed in hepatocellular carcinoma [ J ]. Hepatology, 2003, 38 (1): 178-186.
  • 6HAYASHI Y, MOLINA J R, HAMILTON S R, et al. NHERFI/ EBP50 is a new marker in colorectal cancer [ J ]. Neoplasia, 2010, 12(12) : 1013 -1022.
  • 7MOLINA J R, MORALES F C, HAYASHI Y, et al. Loss of PTEN binding adapter protein NHERF1 from plasma membrane in glioblastoma contributes to PTEN inactivation [J].Cancer Res, 2010, 70(17): 6697-6703.
  • 8GEORGESCU M M. NHERFI : molecular brake on the PI3K path- way in breast cancer[J]. Breast Cancer Res, 2008, 10(2) : 106.
  • 9SONG J, BAI J, YANG W, et al. Expression and clinicopathologi- cal significance of oestrogen - responsive ezrin - radixin - moesin - binding phosphoprotein 50 in breast cancer [ J ]. Histopathology, 2007, 51(1): 40-53.

同被引文献7

  • 1Bellizzi A, Malfettone A, Cardone RA, et al. NHERF1/EBP50 in breast cancer: clinical perspectives[J]. Breast Care (Basel), 2012,5(2):86-90.
  • 2Shibata T, Chuma M, Kokubu A, et al. EBP50, a beta-catenin- associating protein, enhances Wnt signaling and is over-expressed in hepatocellular carcinoma[J]. Hepatology, 2012,38 (1): 178-186.
  • 3Ji H, Liu YE, Jia T, et al. Identification of a breast cancer- specific gene BCSG1, by direct differential cDNA sequencing[J]. Cancer Res, 2012,57(4) :759-764.
  • 4Lavedan C, Leroy E, Dehejia AJ, et al. Synucleins are expressed in the majority of breast and ovarian carcinomas and in preneoplastic lesions ovary[J]. Cancer, 2000,88(9):2154-2163.
  • 5姜展红,杨丽,崔娣,吴宜勇,张毅.癌相关基因蛋白在子宫内膜癌中表达[J].中华实用诊断与治疗杂志,2010,24(6):569-571. 被引量:10
  • 6韦瑞红,黄海玉,彭碧玲.PCNA和P21蛋白在子宫内膜癌中的表达及意义[J].中华实用诊断与治疗杂志,2012,26(6):568-570. 被引量:9
  • 7吴克瑾,翁子毅,林古法,殷敏智,钱惠琴,张一楚,丁小燕.乳腺癌特异基因1在乳腺癌表达的意义[J].上海医学,2004,27(3):193-195. 被引量:18

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部