老年恶性血液病合并真菌感染20例临床分析

Clinical analysis of invastive fungal infections in elderly patients with hematologic malignancies

目的提高对老年恶性血液病患者合并真菌感染的认识，完善治疗措施，减少真菌感染率、死亡率，提高生存率。方法分析住院的老年恶性血液病合并真菌感染患者20例的一般临床资料、病原微生物学检查及治疗情况。结果老年血液肿瘤患者真菌感染的发病率不断增高，病原菌以念珠菌为主，20例患者应用抗真菌药物后总有效率为55％，死亡率为25％。结论真菌感染是老年恶性血液病患者化疗期间严重的并发症和主要的死亡原因之一，早期诊断、经验治疗，具有重要意义；对于高危患者，预防治疗尤为必要。

Objective To improve the understanding of fungal infections in elderly patients with hematologic malig- nancies, to improve the treatment and to reduce fungal infection rate, mortality, improve survival. Method To analyze the clinical data of 20 cases of fungal infections in hospitalized elderly hematologic malignancies patients, pathogenic micro- biology examination and treatment. Results The incidence of fungal infections in elderly patients with hematologic malig- nancies constantly increased. Candida was the most common pathogen. The total treatment effective rate was 55 %, the in- fection-related mortality was 25 %. Conclusion Fungal infection is one of the serious complications and the main cause of death in elderly patients with hematologic malignancies during chemotherapy, early diagnosis and empirical treatment is im- portant. Preventive antifungal treatment is necessary, especially for high-risk patients.