TNF-α,Ang-1,IL-8在COPD合并肺动脉高压发病机制中的作用

Effect of TNF-α,Ang-1 and IL-8 on the pathogenesis of COPD patients combined with pulmonary hypertension

目的研究肿瘤坏死因子α(TNF-α)、血管生成素-1(Ang-1)、白介素-8(IL-8)在COPD合并肺动脉高压发病机制中的意义。方法选取呼吸内科40名COPD患者,分为两组,B组:20名(GOLDⅡ级COPD合并肺动脉高压患者);C组:20名(GOLDⅢ级COPD合并肺动脉高压患者)。各组样本行心脏彩超检查确定肺动脉高压并估算肺动脉高压数值,取血清用酶联免疫法测定TNF-α、Ang-1、IL-8数值,并且各组样本行肺功能检查。结果各组中的Ang-1、TNF-α、IL-8相比较有统计学意义(P<0.05),Ang-1与肺动脉压负相关(P<0.05)、TNF-α与肺动脉高压存在正相关(P<0.05),肺功能与肺动脉压存在负相关(P<0.05)。结论 COPD合并肺动脉高压患者与血管因素及炎症因素均有关系,与血管因素较为密切。

Objective To study the effect of TNF-α, Ang-1 and IL-8 on the pathogenesis of COPD patients combined with pul- monary hypertension. Methods 20 healthy people were taken as the group A, and 40 COPD patients complicated with pulmonary hyper- tension were evenly divided into the group B and the group C based on GOLD levels. The values of pulmonary hypertension were estimated by cardiac color uhrasonography, and the levels of IL-8, TNF-α, and Ang-1 were measured by euzymelinked immunosorbent assay. Re- suits There were significant differences of IL-8, TNF-α, and Ang-1 among the three groups （P 〈 0. 05）. Pulmonary functions and Ang- 1 were negatively correlated with pulmonary arterial pressure, and TNF-α was positively correlated with pulnaonary arterial pressure （ P 〈 0. 05 ）. Conclusion The condition of COPD patients complicated with pulmonary hypertension is correlated with inflammatory factors and blood vessels, and more closely with the later.