AECOPD病原学特点及耐药性分析

Etiological characteristics and resistance analysis of patients with chronic obstructive pulmonary disease at acute exacerbation period

目的了解AECOPD患者病原学特点及耐药情况。方法分析因AECOPD入院患者病原学特点,常用药物的耐药性。结果 AECOPD患者细菌感染的阳性率高,为77.85%,以革兰氏阴性杆菌为主,细菌的耐药率高。治疗时选用β-内酰胺酶抑制剂的复合抗生素及碳青霉烯类抗生素,治愈率高。结论 COPD患者感染以革兰阴性杆菌为主,耐药较普遍,应引起临床足够重视。

Objective To understand etiological characteristics and drug resistance of patients with chronic obstructive pulmonary disease at acute exacerbation period （AECOPD）. Methods The etiological characteristics and drug resistance of AECOPD patients were retrospectively analyzed. Results The positive rate of bacterial infection was 77. 85%, which mainly were gram-negative bacteria with a high drug resistance rate. There was a high cure rate when 13-1actamase inhibitor compound and carbapenem antibiotics were used in the treatment. Conclusion The pathogenic bacteria and etiology of AECOPD patients are various and complicated, which mainly are G-bacil- lus with a drug resistance. The use of β-1actamase inhibitor compound and carbapenem antibiotics has a high cure rate. The use of antibi- otics should be based on the drug resistance test in order to reduce the generation of resistant bacteria. The drug resistance mainly exists in COPD patients and should be paid more attention.