利奈唑胺治疗广泛耐药结核病的临床疗效评价

Evaluation of clinical efficacy of linezolid in the treatment of XDR-TB

目的评价利奈唑胺治疗广泛耐药结核病的临床疗效。方法我院收治的24例广泛耐药结核病患者,随机分为两组,对照组12人采用常规化疗,试验组12人加用利奈唑胺,比较不良反应和疗效。结果试验组试验组症状改善、病灶吸收、空洞闭合、抗酸染色涂片阴性、痰结核分枝杆菌阴性、痰定量PCR阴性例数均明显高于对照组,试验组不良反应发生率高于对照组,差异均有统计学意义(P<0.05),经对症治疗后均痊愈。结论利奈唑胺治疗广泛耐药结核病疗效显著。

Objective To evaluate the clinical effect of linezolid in the treatment of XDR-TB. Methods 24 patients with XDR- TB were randomly and evenly divided into two groups. All of the patients were treated with conventional chemotherapy, and the test group was treated with linezolid additionally. The adverse reactions and curative effects were compared between the two groups. Results The im- provement of symptoms, focus absorption, void closure, acid-fast stain smear negative tuberculosis in sputum, sputum negative, quantita- tive PCR negative cases were more pronounced in the test group than in the control group. The incidence of adverse reactions was higher in the test group than in the control group with statistical significance （ P 〈 0.05 ）, and patients with these adverse reactions were cured by giving related treatment. Conclusion Linezolid has a remarkable curative effect in the treatment of XDR-TB.