音乐治疗对轻、中度阿尔茨海默病患者的影响

The efficacy of music therapy in the treatment of mild and moderate Alzheimer's disease

目的研究音乐治疗对阿尔茨海默病(Alzheimer Disease,AD)患者的影响。方法将60例轻、中度AD患者随机分为研究组和对照组各30例,两组均采用多奈哌齐治疗及常规护理、认知功能训练等基础,研究组在此基础治疗上辅以音乐治疗12周。治疗前后分别对两组进行简易智能状态检查量表(MMSE)、日常生活自理能力量表(ALD)、激越行为量表(CMAI)评分。结果研究组和对照组治疗后MMSE、ADL评分均高于治疗前,差异有统计学意义(P<0.05),而两组CMAI评分均低于治疗前,差异有统计学意义(P<0.05)。治疗后研究组MMSE、ADL评分与对照组比较增高更明显,差异有统计学意义(P<0.05),而研究组CMAI评分与对照组比较降低更明显,差异有统计学意义(P<0.05)。结论音乐治疗对AD患者的认知功能、日常生活自理能力和激越行为均有良好的改善作用。

Objective The study was intended to examine the effectiveness of music therapy in treating patients with Alzheimer＇s disease（AD）. Method 60 AD patients at mild and moderate stages were randomly chosen and divided into an experimental group and a control group for a 12-week study. The primary treatments were identical in each group, including take of Aricept, routine care and cognitive function, and background music is added to the study group. The MMSE, ADL and CMAI scores of the subjects were evaluated pre- and post- treatment. Results The endpoint scores of MMSE and ADL in both groups were higher than pre-treatment （P 〈 0.05） , which was more significant in the study group （ P 〈 0.05 ）. The CMAI scores of endpoint in both groups were lower than pretreatment, which was more significant in the study group（P 〈 0.05 ）. Conclusion Music therapy could ameliorate the cognitive function, daily living abilities and agitated behavior of the AD patients.