麦地霉素在玻碳电极上的阳极伏安法研究

Anodic Voltammetic Behavior of Medecamycin at a Glassy Carbon Electrode

用线性扫描伏安法（ＩＳＶ）、微分脉冲伏安法（ＤＰＶ）和循环伏安法（ＣＶ）在玻碳电极 （ＧＣＥ）上研究了麦地霉素（ＭＤ）在不同介质中的阳极伏安行为。发现在０．１ｍｏｌ／Ｌ Ｎａ_２ＨＰＯ_４溶 液中于０．７５Ｖ（υｓ． Ａｇ／ＡｇＣｌ）左右产生一个阳极氧化峰，峰高与ＭＤ浓度５ × １０^（－５）～１×１０~－１ｇ／Ｌ 范围内呈线性关系。用本法不需分离直接测定了药物制剂和加标尿样。ＲＳＤ为１．８％（ｎ＝ １０）。尿样中ＭＤ的回收率为９５％～１１５％。实验结果表明ＭＤ的电极氧化反应为不可逆过 程。

The anodic voltammetric behavior of medecamycin (MD) in the presence of various electrolytes was studied by linearsweep voltammetry, differential-pulse voltammetry and cyclic voltammetry at a glassy carbon electrode. In phosphate buffer solutions (pH = 9.4), MD is oxidized irreversibly. The peak potential is at about + 0.75 V(υs. Ag/AgCl). The height of the peak is linearly increased with the concentration of MD over the range of 5 x 10^(-5) - 1 x 10^(-1) g/L. The method has been used for the direct determination of MD in tablets. The relative standard deviation (n = 10) is 1. 8%. The recoveries of MD in urine samples are in the range of 95% - 115%.