摘要
用线性扫描伏安法(ISV)、微分脉冲伏安法(DPV)和循环伏安法(CV)在玻碳电极 (GCE)上研究了麦地霉素(MD)在不同介质中的阳极伏安行为。发现在0.1mol/L Na_2HPO_4溶 液中于0.75V(υs. Ag/AgCl)左右产生一个阳极氧化峰,峰高与MD浓度5 × 10^(-5)~1×10~-1g/L 范围内呈线性关系。用本法不需分离直接测定了药物制剂和加标尿样。RSD为1.8%(n= 10)。尿样中MD的回收率为95%~115%。实验结果表明MD的电极氧化反应为不可逆过 程。
The anodic voltammetric behavior of medecamycin (MD) in the presence of various electrolytes was studied by linearsweep voltammetry, differential-pulse voltammetry and cyclic voltammetry at a glassy carbon electrode. In phosphate buffer solutions (pH = 9.4), MD is oxidized irreversibly. The peak potential is at about + 0.75 V(υs. Ag/AgCl). The height of the peak is linearly increased with the concentration of MD over the range of 5 x 10^(-5) - 1 x 10^(-1) g/L. The method has been used for the direct determination of MD in tablets. The relative standard deviation (n = 10) is 1. 8%. The recoveries of MD in urine samples are in the range of 95% - 115%.
出处
《分析化学》
SCIE
EI
CAS
CSCD
北大核心
2000年第8期974-977,共4页
Chinese Journal of Analytical Chemistry