摘要
目的分析重型α-地中海贫血(α地贫)胎儿的二维超声表现,探讨胎儿二维超声检查预测重型α地贫的价值。方法行羊膜腔穿刺术或脐血穿刺术、绒毛穿刺术后确诊重型α地贫且二维超声中有异常表现的胎儿139例(中晚孕胎儿108例,早孕胎儿31例),分析其二维超声的表现,并与正常对照组52例比较。结果 108例重型α地贫中晚期胎儿异常声像表现:胎儿心胸面积比值增大73.1%,胎儿宫内发育迟缓42.6%,胎儿浆膜腔积液36.1%,胎盘增厚35.2%,肠管回声增强29.6%,肝脾肿大17.6%,羊水量异常15.7%,胎儿水肿11.1%,脉络丛囊肿8.3%。31例早孕胎儿胎盘厚度大于正常对照组(P<0.05)。结论二维超声检查是预测重型α地贫胎儿的无创、有效筛查方法,适宜在基层医院推广。
Objective To analyze the two-dimensional ultrasound imaging of fetuses with severe α-thalassemia, and to investigate the clinical value of two-dimensional ultrasound in prediction of severe α-thalassemia in fetuses. Methods One hundred and thirty-nine fetuses with severe α-thalassemia( 108 cases in middle and late gestation, and 31 cases in early gestation) were confirmed by amniocentesis or cordocentesis, chorionic villus sampling, and their abnormal imaging of two-dimensional ultrasound imaging,which was compared with that of normal control group( n = 52), was analyzed. Results Abnormal imaging of 108 fetuses with severe α-thalassemia in middle and late gestation was as follows: increased fetal cardiothoracic ratio (73. 1% ), intrauterine growth retardation (42. 6% ), serous cavity effusions (36. 1% ) ,increased placenta thickness (35.2%), intestinal echo enhancement (29. 6% ), hepatosplenomegaly ( 17.6% ), abnormal amniotic fluid volume ( 15.7% ), edema ( 11.1% ), choroid plexus cysts (8.3%). The placenta thickness of 31 fetuses in early gestation was greater than that of normal control group (P 〈0. 05 ). Conclusion Two-dimensional ultrasound is a noninvasive and effective tool for the prediction of severe α-thalassemia in fetuses, which is suitable for basic level hospital.
出处
《广西医学》
CAS
2013年第2期129-131,134,共4页
Guangxi Medical Journal
基金
国家"十一.五"科技支撑计划项目(2007BAI07A17-11)
广西自然科学基金(0640111)
关键词
Α-地中海贫血
胎儿
二维超声
筛查
α-thalassemia
Fetus
Two-dimensional ultrasound
Screening