摘要
N 1-（2-Fursnidyl）-5-fluorouracil reacted with multimethylenes chlorohydrin in the presence of NaHCO3 in acetonitrile at 80 ℃ to give N 1-（2-furanidyl）-N 3-（hydroxyalkyl）-5-fulorouracils in a high yield （≥93%）. Their cyclic glycerophospholipid conjugates were synthesized and had a good activity against the man urinary bladder cancer cell in vitro.
N 1-(2-Fursnidyl)-5-fluorouracil reacted with multimethylenes chlorohydrin in the presence of NaHCO_3 in acetonitrile at 80 ℃ to give N 1-(2-furanidyl)-N 3-(hydroxyalkyl)-5-fulorouracils in a high yield (≥93%). Their cyclic glycerophospholipid conjugates were synthesized and had a good activity against the man urinary bladder cancer cell in vitro.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2000年第9期1410-1412,共3页
Chemical Journal of Chinese Universities
基金
国家自然科学基金!(批准号 :2 9772 0 18)
国家教育部高等学校重点实验室基金资助
