外周血单核细胞hFgl2蛋白表达与不同临床类型肝病的关系

hFgl2 protein expression in peripheral blood mononuclear cells in different clinical types of liver disease

目的探讨人纤维介素蛋白-2凝血酶原酶(hFgl2)在慢性乙型肝炎及肝癌患者外周血单核细胞中的表达及其与慢性乙型肝炎病情严重程度之间的关系。方法测定慢性乙型肝炎轻、中、重度,慢性重型乙型肝炎,肝癌患者共78例外周血单核细胞hFgl2蛋白的表达进行比较,并将其与配对患者谷丙转氨酶(ALT)、谷草转氨酶(AST)及总胆红素(TBiL)行相关分析。结果hFgl2蛋白可以表达于外周血单核细胞,在慢重肝组和肝癌组表达高于对照组和慢乙肝组,而慢重肝组表达高于肝癌组。慢乙肝重度组hFgl2蛋白的表达与其ALT、AST及TBiL成正相关。结论 hFgl2蛋白可以表达于外周血单核细胞并呈现随着肝病严重程度增加而表达升高的趋势。

Objective To detect hFgl2 expression in peripheral blood mononuclear ceils in patients with chronic hepatitis B and liver cancer and explore its association with the severity of chronic hepatitis B. Methods The protein expression of hFgl2 in peripheral blood mononuclear ceils was detected in 78 patients with chronic hepatitis B （including mild, moderate, or severe cases）, chronic severe hepatitis, or liver cancer, with 20 healthy volunteers as controls. The data were analyzed in comparison with the patients＇ alanine aminotransferase （ALT）, aspartate aminotransferase （AST） and total bilirubin （TBiL and） levels. Results hFgl2 protein expression was significantly higher in patients with chronic severe hepatitis and liver cancer than in the healthy volunteers and patients with chronic hepatitis B. The patients with chronic severe hepatitis had significantly higher hFgl2 protein expression than patients with liver cancer. In severe cases of chronic hepatitis B, hFgl2 protein expression was positively correlated with ALT, AST and TBiL, but these correlations were not found in mild or moderate cases. Conclusions Peripheral blood mononuclear cells express hFgl2 protein, whose expression level increases with the severity of chronic hepatitis B.