高敏C反应蛋白及白细胞介素6在心房颤动并发血栓中的意义

Relationship of high-sensitive C-reactive protein,IL-6 and atrial fibrillation combining with thrombosis

目的:探讨心房颤动(房颤)患者血浆高敏C-反应蛋白(hs-CRP)、白细胞介素6(IL-6)与左房内血栓形成的关系。方法:根据心脏超声检查结果将148例房颤患者分为血栓组(56例)和非血栓组(92例),分别测定两组血浆hs-CRP和IL-6浓度,同时测定左房内径及左室射血分数(LVEF),分析hs-CRP、IL-6与血栓形成的关系。结果:血栓组血浆hs-CRP与IL-6浓度均明显高于非血栓组[(4.38±0.56)g/L∶(1.12±0.27)g/L,(156.6±29.4)ng/L∶(114.5±20.7)ng/L;均P<0.05];Logistic回归发现,高hs-CRP(OR=2.631)、高IL-6(OR=2.965)及左房内径扩大(OR=4.337)是血栓形成的独立危险因素(均P<0.05)。结论:hs-CRP及IL-6升高、左房扩大是房颤患者左房血栓形成的独立危险因素,炎症反应在房颤心房血栓形成过程中可能起重要作用。

Objective： To investigate the alteration of plasma high sensitive C-reactive protein （hs CRP） and interleukin-6 （IL-6） in patients with atrial fibrillation combining thrombosis. Method.. Patients with atrial fibrillation were divided into thrombus group （n： 56） and non-thrombus group （n= 92） according to echocardiography results. The plasma hs-CRP and IL-6 concentrations and LVEF values as well as [eft atrium diameter were measured. Logistic multi-factors regression analysis was performed. Result： Plasma hs-CRP and IL-6 concentrations in thrombus group were significantly higher than those in non-thrombus group [（4.38 ± 0. 56）g/L ： （1.12±0.27）g/L, （ 156.6 ± 29.4） ng/L ： （ 114.5 ± 20.7） ng/L; both P 〈 0.05 ]. Logistic multi-factors regression analysis showed that high plasma concentrations of hs CRP （OR： 2. 631）, IL-6 （OR： 2. 965） and enlarged left atrium diameter （OR= 4. 337） were main independent risk factors of patients with atrial fibrillation combining thrombosis （all P〈 0.05）. Conclusion.. hs-CRP and IL-6 were independent risk factors of patients with atrial fibrillation combining thrombosis. Inflammatory reaction may play an important role in the formation of thrombosis in patients with atrial fibrillation.