Leprdb/db糖尿病小鼠胸主动脉异位移植后的血管重塑

Vascular remodeling after aorta heterotopic grafting in Leprdb/db diabetic mice

目的:探讨糖尿病对小鼠胸主动脉同基因异位移植后血管形态功能变化的影响。方法:将Leprdb/db小鼠与C57BL/6J小鼠的胸主动脉异位移植于同基因小鼠的颈总动脉部位,术后4周进行血管超声检测、血管形态学分析与血管功能测定。结果:术后4周糖尿病小鼠的移植血管管壁增厚、管径变窄,但与对照组比较无明显差异。结论:糖尿病对动脉移植后的血管重塑无明显作用。

Objective：To investigate the effect of diabetes on the changes of vascular function and morphology after isogenic thoracic aorta heterotopic transplanting. Method：Syngeneic heterotopie transplantation of segments of thoracic aortas from Leprdb/db and C57BL/6J mice were grafted into the neck circulation （common carotid artery） of syngeneic mice. Mice were euthanized 4 weeks later, and aorta grafts were analyzed by ultrasonography, morphometry, vascular functional studies. Result： After 4 weeks of transplantation, wall thickness increased and lumen diameter decreased significantly in Leprdb/db transplant mice, but there was no difference in the structural adaptalion of grafts between Leprdh/db and C57BL/6J mice. Conclusion：Diabetes is not critical for vascular remodeling after arterial transplantation.