儿宝颗粒对小儿厌食症动物模型脑肠肽的调节作用

Regulatory Effect of Erbao Granules on Brain Gut Peptide in Juvenile Animal Model of Anorexia

目的 :研究运脾复方儿宝颗粒 (简称儿宝 )对小儿厌食症模型大鼠中枢和外周脑肠肽的调节作用。方法 :模拟小儿厌食症的主要病因制作幼龄大鼠厌食模型 ,并用儿宝治疗 ;应用放免检测技术测定模型大鼠下丘脑、胃窦部和外周血八肽胆囊收缩素 (CCK 8)和 β 内啡肽 ( β EP)的含量。 结果 :模型大鼠中枢和外周血CCK 8含量均增高 (P <0 0 5或P <0 0 1) ,外周血β EP含量减低 (P <0 0 5)。用儿宝治疗后CCK 8显著降低 ,β EP含量显著增加 (P <0 0 5或P <0 0 1)。结论 :儿宝能明显抑制该模型中枢和外周血CCK 8分泌 ,促进β

Objective: To study the regulatory effect of Erbao granules (EBG) on central and peripheral brain gut peptide in juvenile animal model of anorexia. Methods: Juvenile rat model of anorexia was established by imitating the major cause of infantile anorexia and treated with EBG. The cholocystokinin octapeptide (CCK 8) and β endorphin (β EP) concentration in hypothalamus, antrum pyloricum and peripheral blood were examined by radioimmunoassay. Results: CCK 8 concentration in hypothalamus and plasma in the model rats increased (P<0 05), while blood β EP concentration decreased (P<0 05). After EBG treatment, the CCK 8 concentration normalized and β EP increased significantly. Conclusion: EBG could reduce the central and peripheral CCK 8 and increase β EP secretion significantly in the juvenile anorexia model.