补肾益智方治疗老年性痴呆模型大鼠的行为学测试

Ethological Examination of Alzheimer′s Disease Model Rats Treated with Bushen Yizhi Decoction

目的 :探讨补肾益智方对老年性痴呆 (AD)模型大鼠神经行为学的改善作用。方法 :用Mor ris水迷宫 (MWM )技术对青年组、老年正常组 (简称老年组 )、AD模型组 (简称模型组 )、石杉碱甲 (HupA)组和补肾益智方治疗组 (简称治疗组 )进行行为学测试。结果 :治疗组平均逃避潜伏期 (EL)变化曲线位于青年组、老年组和模型组、HupA组之间 ;中环游泳路程百分比、4 0cm环游泳时间、跨平台次数治疗组与老年组比较差异无显著性 ,与模型组比较差异有显著性 (P <0 0 5)。结论

Objective: To explore the ethological improving effect of Bushen Yizhi Decoction (BSYZD) in treating model rat of Alzheimer′s disease (AD). Methods: Ethologic examination was carried out with Morris water maze on young, aged, AD model, Huperzine A treated and BSYZD treated groups of rats. Results: In the BSYZD treated group, the escape latency (EL) curve placed between that of the young, aged and AD model, Huperzine A treated group; the percentage of middle circle swim path, the 40 cm circle swimming time, and the platform crossing times were not different from those in the normal aged group, but were different significantly as compared with the AD model group, P<0 05. Conclusion: BSYZD could ameliorate the behavior deficits of AD model.