维生素C与宫颈癌关系的Meta分析

Meta-Analysis of the Relationship between Vitamin C and Cervical Cancer

目的:探讨维生素C摄入水平与宫颈癌发病之间的关系。方法:检索1980年1月至2012年2月公开发表的有关维生素C摄入水平与宫颈癌关系的研究文献,使用Review Manager 4.2对符合纳入标准的文献按照不同指标进行定量合成分析。结果:①总纳入10篇文献共8066个病例,按各研究文献标准将摄入维生素C的含量分为4个等级(Q1、Q2、Q3、Q4),高于最低含量Q1者视为维生素C摄入量较高。②以每日总摄入量为指标时,维生素C摄入量>Q1组和Q1组两组间比较,病例组和对照组差异有统计学意义(P<0.05);对每日总摄入量Q2、Q3、Q4进行亚组分析,Q2亚组尚不能认为病例与对照组间差异有统计学意义(P>0.05),Q3、Q4亚组组间差异有统计学意义(P<0.05)。③以每日膳食摄入量为指标时,维生素C摄入量>Q1组和Q1组两组间比较,病例组和对照组差异有统计学意义(P<0.05);对每日膳食摄入量Q2、Q3、Q4进行亚组分析,病例与对照组差异均有统计学意义(P<0.05)。结论:较高的维生素C摄入水平是宫颈癌发病的保护因素,且随着维生素C摄入水平的增高,宫颈癌发病风险逐渐降低。

Objective：To explore the relationship between Vitamin C and cervical cancer. Methods：The literatures about the association between Vitamin C and cervical cancer from January 1980 to February 2012 were searched for inclusion and exclusion criteria, and the data in the studies selected were analyzed by Rev- Man 4.2 software. Results ：（~10 studies and a total of 8066 caseswere enrolled in this analysis according to the criteria. The Vitamin C intake was divided into four grade according to every study（Q1 ,Q2,Q3Q4）. For the daily total Vitamin C intake, there were significant differences between cases and controls in the group Q1 and group daily total Vitamin C intake 〉 Q1 （ P 〈0.05）. For sub-group analysis of daily total Vitamin C in- take Q2,Q3 ~Q4, the sub-group of Q2 was not different between cases and controls （ P 〉 0.05）, but there were significant differences between cases and controls in Q3,Q4 （ P 〈 0. 05）. （~For the daily dietary Vitamin C intake,there are significant differences between cases and controls in the group Q1 and group daily dietary Vitamin C intake 〉 Q1 （P 〈 0.05） ; For sub-group analysis of daily dietary Vitamin C intake Q2 ,Q3,Q4, there are significant differences between cases and controls in all three subgroups（ P 〈 0. 05）. Conclusions： High intake of Vitamin C was a protective factor of cervical cancer. Along with the increasing intake of Vitamin C, the risk of cervical cancer was reduced.