育龄护士多囊卵巢综合征流行病学调查研究

The prevalence of polyocystic ovary syndrome in nurses of reproductive age

目的本研究在育龄护士中开展了多囊卵巢综合征（PCOS）的患病率研究，并分析比较PCOS4种表型的特征。方法以2011年在仁济医院工作的育龄护士为调查对象，采用问卷调查、病史采集、体格检查、多毛评分、激素水平测定、妇产科超声检查等方法。结果共计有520人参与问卷调查，486人完成雄激素检查，283人正常，48人多囊卵巢，129人有高雄激素的临床或生化表现，89人稀发排卵或无排卯。鹿特丹标准PCOS患病率11．1％，其4个分型间仅年龄有统计学差异（P〈0．05），其余代谢指标差异无统计学意义。结论本研究显示，育龄期护士中PCOS患病率为11．1％，目前迫切需要对标准中的每个条件进行明确的定义，这可改善研究结果的可比性，同时增加已发表研究的价值。PCOS广泛筛查对于PCOS的早期诊断具有重要意义，可以避免严重并发症的发生。

Objective To explore the prevalence of polycystic ovary syndrome （PCOS） in nurse of reproductive age and compare the characteristics of four phenotypic subgroups. Methods A cross-sectional survey was carried out in nurses aged 18-45 years in Renji Hospital in 2011. Questionnaire and anthropometric and biochemical assessments were made. Pelvic ultrasound evaluations were made and blood androgen levels were determined. Diagnosis of PCOS was based on Rotterdam 2003 criteria, consisting of anovulation/oligo-ovulation （ ANOVU ）, clinical and/or biochemical hyperandrogenism （ HA ） and polycystic ovaries （ PCO ）. Results There were 520 participants and finally 486 individuals finished questionnaire and androgen level determination. 283 subjects were totally normal, 48 suffered from PCO, 129 HA, and 89 ANOVU. 54 out of 486 women were diagnosed as PCOS, a prevalence of 11. 1%. A significant difference exited only in age among four phenotypic subgroups （ P〈 0.05 ）. There was no statistic difference in other parameters. Conclusion Establishing an explicit definition of each condition in PCOS criteria has important investigational implications and increase the comparability of published researches. Application of Rotterdam criteria is feasible for earlier diagnosis and timely intervention in order to prevent serious complications.