2型糖尿病尿钠排泄与颈动脉内膜中层厚度的关系研究

Relationship between urinary sodium excretion and carotid intima-media thickness in type 2 diabetic patients

测定186例2型糖尿病患者24h尿钠排泄量，以四分位数将入选者分为4组，观察其与颈动脉内膜中层厚度关系。随着尿钠排泄量增加，2型糖尿病患者颈动脉内中膜厚度逐步上升（P趋势〈0．01）。回归分析经年龄、吸烟、血压等因素调整后仍显示尿钠排泄增加可能是颈动脉内膜中层增厚的相关因素（／3=0．074，P〈0．01）。

Urinary sodium was measured by means of 24-hour urine collection in 186 patients with type 2 diabetes. All patients were categorized into quartiles of urinary sodium. There was a significant positive trend of association of greater carotid intima-media thickness（CIMT） with increasing urinary sodium quartile, even adjusting for age, smoking, and blood pressure （ Ptrend〈0. 01 ）. Multiple linear regression analysis showed that 24-hour urinary excretion may be associated with CIMT in type 2 diabetes patients （β=0. 074 ,P〈0.01 ）.