摘要
研究胆固醇酯转运蛋白(CETP)对肝脏B族Ⅰ型清道夫受体(SR—B1)基因表达的影响。结果表明CETP转基因小鼠血清中的总胆固醇(TC)、高密度脂蛋白胆固醇低于对照组,但肝脏内的TC、胆固醇酯却高于对照组(P〈0.05),而两组小鼠血清中的甘油三酯差异无统计学意义;CETP转基因小鼠肝脏SR-B1mRNA表达量均显著低于对照组(P〈0.05)。
The effect of cholesterol ester transfer protein (CETP) on SR-B1 mRNA expression in mouse liver was investigated. The results demonstrated that CETP transgenic mice showed lower serum total cholesterol and high density lipoprotein-cholesterol levels but higher total cholesterol and cholesterol ester content in liver when compared with wild type mice(P〈0.05 ). The expression of SR-B1 mRNA in liver of CETP transgenic mice was significantly lower as compared with the control grouP( P〈0.05 ).
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2013年第3期259-260,共2页
Chinese Journal of Endocrinology and Metabolism
基金
国家自然科学基金资助项目(81170747)
江苏省六大人才高峰(2008-18D)
关键词
胆固醇酯转运蛋白
低密度脂蛋白受体
B族Ⅰ型清道夫受体
Cholesterol ester transfer protein
Low density lipoprotein receptor
Scavenger receptor class Btype I