期刊文献+

胆固醇酯转运蛋白对小鼠肝脏SR-B1基因表达的调控

Cholesterol ester transfer protein regulates the hepatic SR-B1 mRNA expression in mice
原文传递
导出
摘要 研究胆固醇酯转运蛋白(CETP)对肝脏B族Ⅰ型清道夫受体(SR—B1)基因表达的影响。结果表明CETP转基因小鼠血清中的总胆固醇(TC)、高密度脂蛋白胆固醇低于对照组,但肝脏内的TC、胆固醇酯却高于对照组(P〈0.05),而两组小鼠血清中的甘油三酯差异无统计学意义;CETP转基因小鼠肝脏SR-B1mRNA表达量均显著低于对照组(P〈0.05)。 The effect of cholesterol ester transfer protein (CETP) on SR-B1 mRNA expression in mouse liver was investigated. The results demonstrated that CETP transgenic mice showed lower serum total cholesterol and high density lipoprotein-cholesterol levels but higher total cholesterol and cholesterol ester content in liver when compared with wild type mice(P〈0.05 ). The expression of SR-B1 mRNA in liver of CETP transgenic mice was significantly lower as compared with the control grouP( P〈0.05 ).
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2013年第3期259-260,共2页 Chinese Journal of Endocrinology and Metabolism
基金 国家自然科学基金资助项目(81170747) 江苏省六大人才高峰(2008-18D)
关键词 胆固醇酯转运蛋白 低密度脂蛋白受体 B族Ⅰ型清道夫受体 Cholesterol ester transfer protein Low density lipoprotein receptor Scavenger receptor class Btype I
  • 相关文献

参考文献7

  • 1Jiang XC, Masuci-Magoulas L, Mar J, et al. Down-regulation of mRNA for the low density lipoprotein ceptor in transgeuic mice containing the gent for human choleslelwl esler transtr protein. Mechanism to explain accumulation of lipoprolein B particles. J Biol Chem, 1993,268:27406-27412.
  • 2Akita N, Tsujita M, Yokota T, et al. High density lipoprotein turnover is dependent on peroxisome proliferator-activated receptor e in mi<'e. J Atheroscler Throml>, 2010,17 : 1149-1159.
  • 3Marlinez MN, Emfinger CH, Overton M, el al. Obesity and altered gl[ucose metabolism impa t HDL composition in CETP transgeni(, mic : a role br ovarian hormones. J l,ipid Res, 2012,53:379-389.
  • 4gorporaal SJ, Meurs I, Hauer AD, et al. l)eletion o|' the high-density lipoprotein receptor scavenger receptor BI in mice modulates thrombosis susceptibility and indirectly affects platelet nclion by elevation of plasma free cholesterol. Arterioscler Thromb Vase Biol, 2011,31:34- 42.
  • 5Kozarsky KF, l)onahee MH, Rigoui A, el al. Overexpression of the HDL receptor SR-BI alters plasma HDI. and bile cholesterol levels. Nature, 1997,387:414-417.
  • 6El Bouhassani M, Giliberl S, Moreal M, el aJ. Cholesteryl ester lransfer protein expression partially attenuates the adverse ell'eels of SR-BI receptor deficiency on cholesterol metabolism and atheroselerosis. J Biol Chem, 2011,286 : 17227-17238.
  • 7Hooper A J, Burnett JR. Anaeetrapib, a cho estel ester transtr protein inhibitor. Expert Opin Investig Drugs, 2019,21:103-109.

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部