Lxn,bcl-2,c-myc在胰腺癌干细胞中的表达及意义
被引量:3
摘要
本研究通过免疫磁珠分选技术分选出胰腺癌细胞株Miapaca-2中的CD133+细胞,并检测lxn,bcl-2,c-mye在CD133+与CD133-细胞中表达,探讨其可能的生物学意义。
出处
《中华普通外科杂志》
CSCD
北大核心
2013年第3期236-237,共2页
Chinese Journal of General Surgery
基金
浙江省自然基金(Y2100546)
参考文献3
-
1Liang Y, Jansen M, Aronow B, et al. The quantitative trait gene latexin influences the size of the hematopoietic stem cell population in mice. Nat Genet, 2007, 39: 178-188.
-
2Kang MH, Reynohls CP. Bel-2 inhihitors: targeting mitoehondrial apoptotic pathways in cancer therapy. Clin Cancer Res, 2009, 15: 1126-1132.
-
3Murphy M J, Wilson A, Trumpp A. More than just proliferation : Mye function in stem cells. Trends Cell Biol,2005, 15:128-137.
同被引文献37
-
1Zhao SH, Zhao F, Zheng JY,el al. Knockdown of stat3 expression by RNAi inhibits in vitro growth of hunmn ovarian cant'er. Radiol Onco1,2011,45 ( 3 ) : 196-203.
-
2Won C ,Lee CS, l,ee JK ,el a]. CADPE suppresses cyclinD1 expres- sion in hepatcn:'elluJar carcinoma by blocking IL-6-induced STAT3 activation. Anticancer Res,2010,30(2 ) :481-488.
-
3麻银雪,黄丽清,许乙威,等.Sq、AT3和CD34在胃癌早期诊断中的价值.中图医师杂志,2013,15(05):586-589.
-
4Volcik KA,Campbell S,Chambless LE,et al. MMP2 genetic varia- tion is assoeiattd with measures of fibrous cap thlckness: The Alh- erosclerosis Risk in Communities Carotid Mill Study. Athercsclero- sis,2010,210(1) :188-193.
-
5Shah Y, Zhang L, Bao Y, et al. Epithelial-mesenchymal transi- tion, a novel largeI of sulfnraphane via COX-2/MMI, 9/Snail, ZEBI and miR-2OOc/ZEBI pathways in human bladder cancercells. J Nutr Biochem ,2013,24 (6) : 1062-1069.
-
6Ferenc P, SolOr P, Kleban J, et al. Down-regulation of Bcl-2 and Akt induced by combination of photoactivated hyperiein and genistein in human breast cancer cells. J Photochem Photobiol B, 2010,98( 1 ) :25-34.
-
7Zapico JM, Serra P, Garcia - Sanmartin J, et al. Potent "clicked" MMP2 inhibitors : synthesis, molecular modeling and biological exploration. Org Biomol Chem, 2011,9 ( 12 ) : 4587-4599.
-
8Lirdprapamongkol K, Sakurai H, Abdelhamed S, et al. Chrysin overcomes TRAIL resistance of cancer cells through Mcl-1 down- regulation by inhibiting STAT3 phospholclation. Int J Oncol, 2013,43 ( 1 ) :329-337.
-
9Zhuang Q, Hong F, Shen A, et al. Pien Tze Huang inhibits tumor cell proliferation and promotes apoptosis via suppressing the STAT3 pathway in a colorectal cancer mouse model, lnt J On- col,2012,40(5 ): 1569-1574.
-
10Reya T,Morrison SJ, Clarke MF,et al. Stem cells, cancer, and cancer stem ceils [ J ]. Nature, 2001,414 (6859) : 105-111.
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-
2郑志强,郑继行,蔡振寨,王成,周香,薛战雄.Lxn对CD133+PANC-1胰腺癌细胞增殖及bcl-2、bax表达的影响[J].中华普通外科杂志,2016,31(1):46-49. 被引量:1
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3王成,蔡振寨,周羽翙,郑继行,薛战雄.Latexin基因转染对CD133^+MIAPaca-2胰腺癌干细胞增殖的影响[J].中华胰腺病杂志,2016,0(1):10-14. 被引量:1
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-
6郭柏华,杨章林,董国钢,王笑凌,班雨.Pokemon和c—mye表达及临床意义在结直肠癌中的[J].中国医师进修杂志,2015,38(8):547-550.
-
7谢晶日,梁国英,任公平,李明.c-myc、ras基因与肝细胞癌的关系[J].中西医结合肝病杂志,2009,19(2):124-126. 被引量:3
-
8朱童,胡学谦,汪妍,于观贞,王杰军.Latexin在胃癌组织中的表达及临床意义[J].临床肿瘤学杂志,2015,20(11):1006-1009. 被引量:2
-
9朱保玉.成釉细胞瘤中Bcl-2、c-myc和PCNA的表达[J].医药论坛杂志,2006,27(1):10-12.
-
10田晓红,侯伟健,柏树令,范军,佟浩,徐赫.XAV939抑制人神经母细胞瘤细胞的增殖[J].解剖学报,2014,45(2):190-195.