双时相与单时相^(18)F-FDG PET/CT对乳腺癌诊断价值的Meta分析

Value of dual phase ^(18)FDG-PET/CT and single phase 18FDG-PET/CT in diagnosis of breast cancer: Meta-analysis

目的评价双时相与单时相18F-FDG PET/CT对乳腺癌的诊断价值。方法计算机检索维普中文科技期刊数据库、中国生物医学文献数据库、中国期刊全文数据库、数字化期刊数据库、PubMed、EMBASE、Web of Science数据库和考克兰图书馆的资源,检索时间为2000年1月1日—2012年1月1日。采用Metadisc 1.4软件对数据进行分析,合并灵敏度、特异度、阳性似然比、阴性似然比及其95%可信区间,采用森林图和I2检验分析异质性,绘制出汇总受试者工作特征(SROC)曲线,计算曲线下面积(AUC)。结果 4篇文献符合纳入要求,合计252例患者,共274个结节。双时相PET/CT和单时相PET/CT的合并灵敏度分别为0.81(95%CI:0.75～0.85)和0.60(95%CI:0.54～0.67);合并特异度分别为0.83(95%CI:0.74～0.89)、0.54(95%CI:0.44～0.64);SROC曲线下面积分别为0.87和0.58。结论双时相18F-FDG PET/CT对乳腺癌的诊断价值较高,与单时相18F-FDG PET/CT相比灵敏度和特异度均较高。诊断乳腺癌时,有必要在常规PET/CT扫描1.5～4.0h后进行延迟扫描。

Objective： To assess the value of dual phase 18F-FDG PET/CT and single phase 18F-FDG PET/CT in diagnosis of breast cancer. Methods： Data stemmed from VIP, CBM, CNKI, Wanfang Data, PubMed, EMBASE, Web of Science and Cochrane Library, the retrieval time was from Jan 1st 2000 to Jan 1st 2012. Metadisc 1.4 was used for data analysis, and the area under curve （AUC） of summary receiver operating characteristic （SROC） curve was calculated. Results： Finally 4 articles were enrolled, involving 252 patients with 274 nodules. The sensitivity of dual phase 18F-FDG PET/CT and single phase 18F-FDG PET/CT was 0.81 （95%CI： 0.75-0.85） and 0.60 （95%CI： 0.54-0.67）, respectively, while the specificity was 0.83 （95%CI： 0.74-0.89） and 0.54 （95%CI： 0.44-0.64）, and AUC of SROC curve was 0.87 and 0.58, respectively. Conclusion： Dual phase 18F-FDG PET/CT can be regarded as an effective and feasible method for diagnosis of breast cancer, which has higher sensitivity and specificity than single phase 18F-FDG PET/CT. For diagnosing breast cancer, it is necessary to conduct delayed scanning 1.5-4.0 hours after conventional PET/CT scan.