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肿瘤干细胞与肿瘤转移的关系 被引量：11

Relationship between cancer stem cells and tumor metastasis
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摘要 肿瘤干细胞(CSCs)对细胞毒性药物具有先天性的抵抗能力,与肿瘤细胞的运动性,侵袭性和抗凋亡能力密切相关。上皮/间质转化(EMT)是指在各种因素作用下上皮细胞转变为具有高侵袭、转移能力间质表型的过程,与CSCs关系密切。笔者就CSCs的EMT现象与肿瘤转移,CSCs定植和趋化作用与转移瘤形成,CSCs与临床治疗的关系研究进展作一综述。 Cancer stem cells （CSCs） are endowed with an inherent resistance to cytotoxic drugs, and are closely related to the migration, invasiveness and anti-apoptotic ability of the cancer cells. Epithelial-mesenchymal transition （EMT） is a process where epithelial ceils acquire the highly invasive and metastatic characteristics of mesenchymal cells, and it has a close connection with CSCs. In this paper＇ the authors address the recent progress in relationship between the EMT status of CSCs and tumor metastasis, and between the localization and chemotaxis of CSCs and the formation of the metastatic colonies, as well as the relation of CSCs with the therapeutic strategy for cancer treatment.
作者 吕阳 许戈良
机构地区 安徽医科大学附属省立医院肝脏外科/肝胆胰外科安徽省重点实验室
出处 《中国普通外科杂志》 CAS CSCD 北大核心 2013年第3期359-362,共4页 China Journal of General Surgery
基金 安徽省2011年度第二批科技计划项目(11010402163) 安徽省2011年度第三批科技计划项目(1106c0805028)
关键词 肿瘤干细胞 肿瘤转移 上皮间质转化 综述文献 Neoplastic Stem Cells Neoplasm Metastasis Epithelial-Mesenchymal Transition Review
分类号 R730.2 [医药卫生—肿瘤]
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参考文献31

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二级参考文献30

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  • 9O'Brien CA, Pollett A, Gallinger S, et al. A human colon cancer cell capable of initiating tumor growth in immunodeficient mice [ J ]. Nature, 2007, 445(7123) :106-110.
  • 10Ricei-Vitiani L, Lombardi DG, Pilozzi E, et al. Identification and expansion of human colon-cancer-initiating cells [ J ]. Nature, 2007, 445(7123) :111 -115.

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引证文献11

二级引证文献73

中国普通外科杂志
2013年 第3期

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