肺表面活性蛋白D与IL-16在变应性鼻炎及鼻息肉中的表达和意义

Expression and significance of pulmonary surfactant protein D and IL-16 in allergic rhinitis and nasal polyps

目的:检测肺表面活性蛋白D(SP-D)及IL-16在变应性鼻炎鼻黏膜组织和鼻息肉组织中的表达情况,探讨SP-D及IL-16在变应性鼻炎和鼻息肉发病中的作用及意义。方法:采用免疫组织化学方法分别检测15例鼻中隔偏曲伴变应性鼻炎患者下鼻甲黏膜组织(变应性鼻炎组)、15例鼻息肉组织(鼻息肉组)和15例下鼻甲黏膜组织(对照组)中SP-D及IL-16表达。结果:SP-D、IL-16在3组中均有表达,但在变应性鼻炎组和鼻息肉组的表达均明显高于对照组(均P<0.01);SP-D和IL-16在变应性鼻炎组和鼻息肉组中的表达相比较差异无统计学意义(P>0.05)。结论:SP-D及IL-16在正常组织和病变组织中均有表达。SP-D可能参与了变应性鼻炎和鼻息肉的炎症反应过程。IL-16是变应性鼻炎和鼻息肉病变中重要的嗜酸粒细胞趋化因子,并增强了嗜酸粒细胞的局部作用,参与了变应性鼻炎和鼻息肉的病变过程。

Objective： To detect the expression and distribution of the lung surfactant protein D（surfactant protein D,SP-D ） and IL-16 in nasal mucosa of allergic rhinitis and nasal polyps,and then probe into their signifi- cance in the pathology of allergic rhinitis and nasal polyps. Method ： Fifteen cases of allergic rhinitis, fifteen cases of nasal polyps and fifteen cases of inferior turbinate mucosa were studied to detect the expression of SP-D and IL-16 by immunohistochemistry method. Result： The expression of SP-D and IL-16 in allergic rhinitis and nasal polyps were dramatically higher in controls（P〈0.01）. There was no remarkable difference in the expression of SP-D and IL-16 between allergic rhinitis and nasal polyps（P〉0.05）. Conclusion：Both normal tissue and diseased tissue ex- press SP-D and IL-16. SP-D is likely to play key roles in the inflammatory reaction process of allergic rhinitis and nasal polyps. IL-16 is an important eosinophil chemokine in the process of allergic rhinitis and nasal polyps, and it can also enhance the local role of eosinophils,thus it can involve in the process of allergic rhinitis and nasal polyps disease.