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壳聚糖丝心蛋白包药微球的结构和释放性能研究 被引量:15

STUDIES ON THE STRUCTURE AND CONTROLLED RELEASE OF CHITOSAN/FIBROIN MICROSPHERE INCLUSION DRUG
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摘要 Miscibility of the fibroin, which was soluble in CaCl\-2\|H\-2O\|C\-2H\-5OH aqueous solution, mixed with chitosan was investigated, and its microspheres were prepared. The chitosan (CS)/fibroin (FB) microsphere inclusion fenoprofen calcium (CS\|FB\|FC) was prepared, and its structure was analyzed by FTIR, X\|ray and SEM. The results indicated that blend of chitosan, fibroin and fenoprofen calcium in aqueous solution is miscible, and strong interaction caused by intermolecular hydrogen bonding exits in CS\|FB\|FC. It was indicated that approximately 77% of fenoprofen from the microsphere were released in phosphate\|buffered saline(pH=7.4) within the initial 6h, and with increasing the glutaraldehyde concentration, the release of fenoprofen decreased. Miscibility of the fibroin, which was soluble in CaCl\-2\|H\-2O\|C\-2H\-5OH aqueous solution, mixed with chitosan was investigated, and its microspheres were prepared. The chitosan (CS)/fibroin (FB) microsphere inclusion fenoprofen calcium (CS\|FB\|FC) was prepared, and its structure was analyzed by FTIR, X\|ray and SEM. The results indicated that blend of chitosan, fibroin and fenoprofen calcium in aqueous solution is miscible, and strong interaction caused by intermolecular hydrogen bonding exits in CS\|FB\|FC. It was indicated that approximately 77% of fenoprofen from the microsphere were released in phosphate\|buffered saline(pH=7.4) within the initial 6h, and with increasing the glutaraldehyde concentration, the release of fenoprofen decreased.
出处 《高分子学报》 SCIE CAS CSCD 北大核心 2000年第4期502-505,共4页 Acta Polymerica Sinica
基金 上海中金投资集团和中科院广州纤维素化学开放实验室资助
关键词 壳聚糖 丝心蛋白 非诺洛芬钙 缓释 包药微球 Chitosan, Fibroin, Fenoprofen calcium, Blend microsphere, Controlled release
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