摘要
Miscibility of the fibroin, which was soluble in CaCl\-2\|H\-2O\|C\-2H\-5OH aqueous solution, mixed with chitosan was investigated, and its microspheres were prepared. The chitosan (CS)/fibroin (FB) microsphere inclusion fenoprofen calcium (CS\|FB\|FC) was prepared, and its structure was analyzed by FTIR, X\|ray and SEM. The results indicated that blend of chitosan, fibroin and fenoprofen calcium in aqueous solution is miscible, and strong interaction caused by intermolecular hydrogen bonding exits in CS\|FB\|FC. It was indicated that approximately 77% of fenoprofen from the microsphere were released in phosphate\|buffered saline(pH=7.4) within the initial 6h, and with increasing the glutaraldehyde concentration, the release of fenoprofen decreased.
Miscibility of the fibroin, which was soluble in CaCl\-2\|H\-2O\|C\-2H\-5OH aqueous solution, mixed with chitosan was investigated, and its microspheres were prepared. The chitosan (CS)/fibroin (FB) microsphere inclusion fenoprofen calcium (CS\|FB\|FC) was prepared, and its structure was analyzed by FTIR, X\|ray and SEM. The results indicated that blend of chitosan, fibroin and fenoprofen calcium in aqueous solution is miscible, and strong interaction caused by intermolecular hydrogen bonding exits in CS\|FB\|FC. It was indicated that approximately 77% of fenoprofen from the microsphere were released in phosphate\|buffered saline(pH=7.4) within the initial 6h, and with increasing the glutaraldehyde concentration, the release of fenoprofen decreased.
出处
《高分子学报》
SCIE
CAS
CSCD
北大核心
2000年第4期502-505,共4页
Acta Polymerica Sinica
基金
上海中金投资集团和中科院广州纤维素化学开放实验室资助
关键词
壳聚糖
丝心蛋白
非诺洛芬钙
缓释
包药微球
Chitosan, Fibroin, Fenoprofen calcium, Blend microsphere, Controlled release
