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噬菌体裂解酶作为抗菌药物的研究进展 被引量:10

Prospects of bacteriophage endolysins as antibacterial agents
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摘要 传统抗菌药物的耐药问题日益突出,促使人们开始寻求更好的新型抗菌物质。噬菌体裂解酶是由双链DNA噬菌体编码、依靠宿主菌合成的酶,其能特异、高效地水解细菌的细胞壁,使细菌裂解死亡。噬菌体裂解酶在体外及动物体内模型实验中显示出良好的杀菌作用,且至今尚无直接对人体产生毒性的报道,噬菌体裂解酶的特性使其在预防、治疗细菌感染方面拥有广阔的应用前景。 At present, there is an urgent need for better novel antibacterial agents due to the dramatic rise in antibiotic resistance among bacteria. Bacteriophage endolysins, encoded by dsDNA phages, synthesized by host bacteria, will result in bacteria death by inducing the lysis of bacteria cell wall specifically and effectively. Studies in vitro and in vivo have demonstrated that endolysins are possessed of strong bactericidal effect without any direct adverse effects, and have broad prospects of application in prophylaxis and treatment of bacterial infections. The prospects of bacteriophage endolysins as antibacterial agents are introduced in this article.
出处 《上海交通大学学报(医学版)》 CAS CSCD 北大核心 2013年第3期368-373,共6页 Journal of Shanghai Jiao tong University:Medical Science
关键词 噬菌体裂解酶 抗菌药物 耐药性 bacteriophage endolysins antibacterial agents bacterial resistance
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参考文献64

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同被引文献129

  • 1陈晓春,王继文,曹永长,毕英佐,马静云.噬菌体在疾病治疗方面的应用及研究[J].动物医学进展,2005,26(1):32-35. 被引量:27
  • 2杨信怡,游雪甫,蒋建东.溶葡球菌酶的抗菌活性研究进展[J].中国新药杂志,2005,14(9):1113-1117. 被引量:12
  • 3孙秋艳,刘红芹,胡晓娜,路建彪,朱瑞良.鸡奇异变形杆菌的分离、鉴定及流行病学调查[J].家畜生态学报,2006,27(6):115-119. 被引量:21
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