p27^(kipl)在胃癌的表达及预后意义

Expression of p27^(kipl) in Gastric Carcinoma and Its Prognostic Significance

目的 研究 p2 7kipl在胃癌组织中的表达和生物学行为及对预后评价的意义。 方法 以免疫组织化学方法检测 92例胃癌组织中 p2 7kipl表达水平。 结果 92例胃癌中 ,p2 7kipl蛋白阳性 39例 (4 2 .4% ) ,其中弱阳性 2 8例 (71.8% ) ,强阳性 11例 (2 8.2 % )。在胃癌组织中 ,p2 7kipl蛋白水平与胃壁浸润深度、TNM分期、病理组织学分级、区域淋巴结转移等均相关。单因素生存分析 ,p2 7kipl高表达组 3,5年生存率分别为 77.1% ,5 7.8% ,明显高于低表达组 33.7% ,2 6 .3% (P=0 .0 0 2 )。Cox回归模型多因素分析显示 ,p2 7kipl是一个独立的预后指标 (P=0 .0 0 0 3)。 结论 p2 7kipl在胃癌中表达降低 ,可作为反映肿瘤恶性表型的指标 。

Objective\ To study the expression of p27\+\{kipl\} in gastric carcinoma in relation to biological behavior and prognosis.\ Methods\ p27\+\{kipl\} expression at protein level were determined by immunohistochemistry technique in 92 patients with gastric carcinoma.\ Results\ 39 cases(42 4%) expressed p27\+\{kipl\} in this group.\ Of the 39 positive patients,p27\+\{kipl\} expression was low in 28(71 8%) and high in 11(28 2%).\ p27\+\{kipl\} expression level correlated with histological grade,depth of invasion,lymph-node metastasis and pTNM stage(P<0 05).\ Univariate analysis demonstrated better survival in patients with higher p27\+\{kipl\} expression than in those with lower expression.\ By Cox multivariate analysis,p27\+\{kipl\} expression level was found to be of independent prognostic significance.\ Conclusion\ p27\+\{kipl\} could be a useful marker indicator for reflecting tumorous malignant phenotype and favors prognosis of gastric cancer. \;