骨巨细胞瘤微血管密度的测定

Determination of Microvessel Density in Giant Cell Tumor of Bone

目的 探讨骨巨细胞瘤病理分级与微血管密度的关系。 方法 将 36例骨巨细胞瘤进行免疫组织化学 SP法染色 ,然后在 Olympus显微镜 (10× 2 0 )下进行微血管密度的计数。 结果 骨巨细胞瘤 、 和 级的微血管密度平均值分别是 2 2 .342 9,2 2 .2 72 7和 2 6 .0 5 71。经统计学方差分析发现各病理分级之间的微血管密度差异均无显著性 (P>0 .0 5 )。 结论 传统的 Jaffe分级可能在反映骨巨细胞瘤的生物学行为方面存在一定的局限性。

Objective\ To study the correlation between pathologic grading and microvessel density(MVD) in giant cell tumor of bone. \ Methods\ 36 cases of giant cell tumor of bone were stained with immunohistochemical SP method,and then microvessel density counted using Olympus microscope(20 objective and×10 eye piece).\ Results\ The mean of MVD in various tumor grades were 22.3429, 22.2727 and 26.0571.\ The microvessel density did not correlate with the histopathological grading by using analysis of variance(P>0 05).\ Conclusion\ Jaffe pathologic grading system has a limited utility for predicting the tumor's biologic behavior.\;