908例急性下呼吸道感染住院儿童病毒病原学研究

908 cases of acute lower respiratory tract infection hospitalized children virus etiology research

目的:分析桂东地区住院急性呼吸道感染患儿病毒特异性抗体(IgM)检测结果,探讨临床儿童急性呼吸道感染病毒病原学情况,而提供病原学诊断依据,指导临床诊断和治疗。方法:选择急性呼吸道感染患儿,取其血液用XK2100生物芯片进行检测筛查4种常见呼吸道病毒的特异性抗体(IgM),包括呼吸道合胞病毒(RSV)、腺病毒(ADV)、流感病毒(IV)及副流感病毒(PIV),对检测标本阳性的病例进行统计分析。结果:908份标本中有235份检出了病毒特异性抗体(IgM)阳性,总检出率为25.88%,其中ADV最为常见,检出率为20.26%,其次为IV(9.14%),RSV(3.63%),PIV(1.76%)。检出率在男女之间差异无统计学意义(P>0.05)。病毒阳性检出率在各年龄组之间差异有统计学意义(χ2=92.549,P<0.001),以4～5岁年龄组检出率最高。病毒总检出率在四季分布差异有统计学意义(χ2=101.011,P<0.001),以夏季检出率最高。结论:病毒病原在桂东地区儿童ALRTI中占重要地位,其中ADV、IV是主要病毒病原,病毒检出率以4～5岁年龄组检出率最高;夏季病毒总检出率高于其他季节。

Objective To analysis in children with acute respiratory tract infection virus-specific antibodies in Guidong area(IgM) test resμlts,study the situation of pathogenic virus in clinical acute respiratory infection in children,and to provide basis for etiological diagnosis,guide the clinical diagnosis and treatment.Methods Acute respiratory tract infection,specific antibodies from the blood with the XK2100 biochip detection screening of 4 kinds of common respiratory virus(IgM),including respiratory syncytial virus(RSV),adenovirus(ADV),influen za virus(IV) and parainfluenza virus(PIV),were detected by statistical analysis was made.Results The 235 samples of the virus specific antibody in 908 samples(IgM) positive,the total positive rate was 25.88%,in which ADV is the most common,the detection rate was 20.26%,followed by IV(9.14%),RSV(3.63%),PIV(1.76%).The detection rate between men and women had no significant difference(P>0.05).Virus positive rate among all age groups had significant difference(χ2=92.549,P<0.001),with 4~5 age group was the highest.Virus detection rate was statistically significant in the four seasons distribution difference(χ2=101.011,P<0.001),the highest detection rate in summer.Conclusion Viral pathogens of children's ALRTI occupies the important position in eastern region,where ADV,IV is the main pathogenic virus,virus detection rate with 4~5 age group was the highest in summer;virus detection rate higher than other seasons.