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HOZOT细胞及其生物学特性研究进展

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摘要 Sakaguchi等早期研究发现体外存在一类具有免疫调节功能的CD4+CD25+调节性T细胞亚群(regulatory Tcells)命名为Treg细胞。
出处 《实用医学杂志》 CAS 北大核心 2013年第6期1016-1017,共2页 The Journal of Practical Medicine
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参考文献9

  • 1Harashima A, Toraya T, Okochi A, et al. Interleukin-8 and RANTES are signature cytokines made by HOZOT, a new type of regulatory T cells [J]. Mol Immunol, 2009,46 (16) :3310- 3319.
  • 2Nakamura S. Discovery of a new type of human regulatory T cell lines, HOZOTs and their clinical application [J]. Nihon Rinsho Meneki Gakkai, 2009,32(4) : 223-230.
  • 3Takeuchi M, Inoue T, Otani T. Cell- in-cell structures formed between human cancer cell lines and the cytotoxic regulatory T-cell line HOZOT [J]. J Mol Cell Bio, 2010,2(3): 139-151.
  • 4Inoue T, Tsshiro Y, Takeuchi M, et al. Potent anti-tumor killing activity of the multifunctional Treg cell line HOZOT against hunmn tumors with diverse origins [J]. Internat J oncol, 2011,38(5): 1299-1306.
  • 5Sugimoto A, Suzuki M, Otani T, et ai. HOZOTs, novel human regulatory T cell lines, exhibit helper or suppessor activities depending on dendritic cell or anti-CD3 stimulation [J]. Exp Hematol, 2009,37 (12) : 1454-1463.
  • 6Otani T, Tsuji-Takayama K, Okochi A, et al. Stromal cells' B7-1 is a key stimulatory molecule for interleukin-10 production by HOZOT, a multifuncti- onal regulatory T-cell line [J]. Immunol Cell Biol, 2011,89 (2) : 246-254.
  • 7Tsuji-Takayama K, Suzuki M, Yamamoto M, et al. IL-2 activation of STATS enhances production of IL-10 from human cytotoxic regulatory T cells, HOZOT [J]. Exp Hemtol, 2008,36(2) : 181-192.
  • 8Tsuji-Takayama K, Suzuki M, Yamamoto M. The production of IL-10 by human regulatory T cells is enhanced by IL-2 through a STAT5- responsive intronic enhancer in the IL- 10 locus [J]. J Immunol, 2008,181 (6) : 3897-3905.
  • 9Harashima A, Toraya T, Okochi A, et al. Interleukin-8 and RANTES are signature eytokines made by HOZOT,a new type of regulatory T cells [J]. Mol Immunol, 2009,46 ( 16 ) : 3310-3319.

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