正交试验法优选参桃软肝胶囊的提取工艺

Optimization of Extraction Technology of Shentao Ruangan Capsule by Orthogonal Test

目的研究参桃软肝胶囊的提取工艺。方法采用正交试验设计的方法,分别对胶囊的醇提和水提工艺进行研究,以人参皂苷Rb1及大黄酚的转移率与干膏得率为指标,进行加权评分,优选提取工艺。结果确定人参、当归、丹参药材最佳醇提条件为75%乙醇,加醇量为7倍,提取时间1 h,提取2次;生大黄、仙鹤草、桃仁等药材水提取条件为浸泡0.5 h,提取时间为1.5 h,提取3次,加水量依次为9,7,7倍。结论该工艺合理可行,适用于参桃软肝胶囊的提取。

Objective To study the extraction technology of Shentao Ruangan Capsule. Methods An orthogonal test was used to optimize the extraction condition. The contents of ginsenoside Rbl and chrysophanol, and the yield of dt7 paste were adopted as the indices for optimizing the ethanol extraction technology and water extraction technology. Re- suits The optimal ethanol extraction technology for Radix Genseng, Radix Angelicae Sinensis, and Radix Salviae Mihiorrhizae was extracting for 1 h each time and for two times with 7 times of 75 % ethanol. The optimal water extrac- tion technology for raw Radix et Rhizoma Rhei, Herba Agrimoniae, Semen Persicae was soaking for 0.5 h and extract- ing for 1.5 h each time and for 3 times with 9, 7, 7 times of water in order. Conclusion The optimal extraction technologies are reasonable and suitable for the extraction process of Shentao Ruangan Capsule.