摘要
目的 为了进一步探讨抗抑郁药作用的分子机制。方法 采用原位杂交技术 (地高辛标记的BDNFcDNA探针 )检测长期给予抗抑郁药氟西汀及生理盐水大鼠海马神经元BDNFmRNA的表达。结果 与生理盐水组相比 ,氟西汀组表达增强 ,尤以CA3、CA1区为甚。
AIM To explore the molecular mechanism of antidepressant action of fluxetine. METHODS In situ hybridization technique (BDNF cDNA Probe labeled with digoxigenin) was used to examine the expression of BDNF mRNA in hippocampal neurons of rats after chronic administration of fluxetine and saline. RESULTS Contrary to saline group, the expression of BDNF mRNA was increased in fluxetine group, especially in CA3 and CA1 regions of hippocampus. CONCLUSION This change of BDNF in hippocampus induced by fluxetine may relate to its after receptor molecular mechanism of antidepressant effect.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2000年第4期453-455,共3页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助课题 !No 396 70 2 72
