ΔFosB在药物依赖性中的介导作用

Role of ΔFosB in mediating drug dependence

Fos转录因子家族包括Fra 1,、Fra 2 ,、FosB和ΔFosB ,其中 ,对来源于fosB基因的ΔFosB发现最晚、了解最少。ΔFosB在脑功能的长时程调节中具有重要作用 ,能很好地解释依赖性药物所致的长期行为变化。可卡因、吗啡、尼古丁和苯丙胺慢性处理后 ,甚至在戒断行为消失后很长时间 ,可显著增加动物脑中的ΔFosB表达 ,但急性依赖性药物处理后却不能。这些研究证据表明 。

Fos family of transcription factor include Fra 1, Fra 2, FosB, and ΔFosB. The latest found and the smallest known Fos family protein is ΔFosB, derived from the fosB gene via alternative splicing.ΔFosB plays an important role in the long term regulation of brain function, and explain the long lasting behavior response to addictive drug well. Chronic cocaine, morphine, nicotine and amphetamine treatment increases strongly expression of ΔFosB in animal brain, even long time after withdrawal behavior disappears. But acute addictive drug treatment does not increase it. The evidence supports the view that ΔFosB is an important transcription factor in long lasting drug dependence.