利培酮片合用舒肝解郁胶囊对阴性症状为主精神分裂症患者认知功能的影响

The Effect of Risperidone Combined with Shuganjieyu Capsule on Cognitive Function of Schizophrenics with Negative Symptoms

目的比较单用利培酮片以及利培酮片合用舒肝解郁胶囊对阴性症状为主的精神分裂症患者认知及社会功能的影响及差异。方法采用阳性与阴性症状量表(PANSS)评定精神症状,威斯康星卡片分类测验(WCST)、连线测验(TMT)、大体功能评定量表(GAF)评定患者的认知及大体功能。结果入组8周合用组正确应答数、错误应答数、持续错误数、完成分类数、TMT-A及TMT-B完成时间、GAF分数(t=-3.117,2.851,2.870,-3.344,12.377,8.988,-18.308;P均<0.01),单用组TMT-A及TMT-B完成时间、GAF评分(t=8.930,7.170,-18.976;P均<0.001),与入组时比较差异有统计学意义;入组8周3组间正确应答数、错误应答数、持续错误数、完成分类数、TMT-A及TMT-B完成时间差异均有统计学意义(F=6.425,5.456,3.066,6.006,3.285,136.141,P均<0.05),合用组正确应答数、GAF分数高于单用组,持续错误数、TMT-B完成时间低于单用组,差异均有统计学意义(P<0.05)。结论利培酮片合用舒肝解郁胶囊对阴性症状为主的精神分裂症患者认知功能的改善优于单用利培酮片治疗。

Objective To compare the efficacy produced by risperidone alone and risperidone combined with shuganjieyu capsule on cognitive and social function of schizophrenics with negative symptoms. Methods Positive and Negative Syndrome Scale for schizophrenia was adopted to evaluate the efficacy of schizophrenics. Wisconsin Card Sorting Test, Trail Making Test, Global As- sessment Function were adopted to analyze the influence on cognitive and social function of schizophrenics after treatment. Results Patients in combination group at eight weekends had lower scores of number of error response,sustained error response,time of link,and higher scores of global assessment function and true response,accomplish classes than those at pre--treatment （t = 2. 851, 2. 870,12. 377,8. 988,-3. 117,-3. 344;P〈0.01）. Patients in alone group at eight weekends had less time of link A and B,and higher scores of global assessment function than those at pre-treatment （t = 8. 930, 7. 170,-18. 976;P〈 0. 001）. At the eighth week, patients in combination group had higher scores in number of error response, time of link than those in control group. Patients in alone group had higher scores in number of error response, sustained error response, time of link, and lower scores of true re- sponse,accomplish classes at the eighth week than those in control group （F= 6. 425,5. 456,3. 066,6. 006,3. 285,136. 141;P〈 0. 05）. The number of true response,global assessment function at eight weekends in combination group were higher than those in alone group（P〈0. 05）. The number of sustained error response ,time of link B at eight weekends in combination group were lower than those in alone group （P〈0. 05）. Conclusion The efficacy on cognitive and social function of risperidone combined with shuganjieyu capsule is superior to risperidone alone in inproving cognitive function of schizophrenics with negative symptoms.