躯体化障碍患者认知功能与P300的相关性

A Correlation between Cognitive Function and P300 in Patients with Somatization Disorder

目的探讨躯体化障碍患者认知功能情况及事件相关电位P300特征。方法随机将年龄在18～60岁之间符合CCMD-3躯体化障碍诊断标准患者40例作为研究组,选择40例健康者作为对照组。两组分别给予事件相关电位P300检测和洛文斯顿认知评定量表测定,将两组测定结果加以比较。结果与对照组相比,实验组N1、P2、N2、P3波潜伏期明显延长(t=2.62,2.51,3.10,3.07;P<0.05或0.01),实验组P2、P3波幅明显降低(t=4.58,4.04;P<0.01);实验组洛文斯顿认知评定量表中7个因子分及总分值均低于对照组,具有统计学差异(t=2.37,2.64,4.14,8.12,2.14,6.08,2.66,5.12;P<0.05或0.01);实验组潜伏期及波幅与洛文斯顿认知评定量表中7个因子分及总分值具有相关性:潜伏期与各因子分及总分值呈负相关(P<0.01),波幅则呈正相关(P<0.01)。结论躯体化障碍患者存在认知功能损害,P300可作为评价躯体化障碍患者认知功能的客观指标。

Objective To investigate the cognitive function and event related potential characteristic of patients with somatiza tion disorders. Methods A total of 40 patients（among 18- 60 years old）met with CCMD--3 for somatization disorders criteria were recruited as research group. 40 matched sexual and age healthy adolescents were selected as normal control group. Loewenstein occupational therapy cognitive assessment （LOTCA）was employed to investigate the cognitive ability of the subjects. P300 poten- tials were recorded with all the subjects and correlated with the LOTCA scores. A comparison was made between the patients and the healthy subjects. Results The latencies of N1,P2,N2and P3 were significantly longer in patients with somatization disorder than those in normal controls（t=2.62,2.51,3.10,3.07;P〈0.05 or 0.01） ,the amplitudes of P2 and P3 were significantly lower in patients （t = 4.58,4.04;P〈0.01）. Seven factors scores and the total score of LOTCA test in patients with somatization disorder were significantly lower than those in normal controls（t：2.37,2.64,4.14,8.12,2.14,6.08,2.66,5.12;P〈0.05 or 0.01）. There was significant correlation between the latency and seven factors scores of LOTCA as well as between the amplitude of P300 and seven factors scores of LOTCA：the latency was negatively correlated with factors scores and amplitude was positively correlated with the LOTCA scores（P〈0.01）. Conclusion Patients with somatization disorders present impaired cognitive function. P300 potentials can be used as a clinical index for appraising the cognition ability of patients with somatization disorder.