小剂量米非司酮与左旋18-甲基炔诺酮单方用于紧急避孕的比较研究

A Comparative Study of Mifepristone and LNG for Emergency Contraception

目的:探讨小剂量米非司酮与左旋18-甲基炔诺酮单方用于紧急避孕的有效性和可接受性。方法:房事后服米非司酮10mg,12小时后服安慰剂一片。房事后服左旋18-甲基炔诺酮0.75mg,间隔12小时再服1次。两种药物外形一致,采用双盲法给药。结果:两药均取得满意避孕效果。但就副反应而言,米非司酮为优,两组发生率差异有显著性(u=4.88,P<0.01)。两药对缩短月经周期的机率无显著性差异(P>0.05),对延长月经周期者米非司酮明显多于左旋18-甲基炔诺酮(u=6.66,P<0.01)。结论:小剂量米非司酮可有效地阻止非意愿妊娠,且服用方便,副作用小。

Objective: To explore the efficacy and acceptability of mifepristone and LNG in treating emergency contraception. Methods:Mifepristone 10 mg was taken right after coitus,and a pill of placebo was then used with a interval of 12 hours. Also,LNG 0.75 mg was taken right after coitus with the same interval for the second LNG taking. Double blind method was adopted in this study. Results:The satisfactory results of contraception were obtained from the treatment with mifepristone and LNG. The side effect incidence in mifepristone treatment group was lower than that in LNG group( u = 4.88, P< 0.01).There was no significant difference in shortening menstrual cycle between two groups(P >0.05). The effect of mifepristone in prolonging menstrual cycle was more significant than that of LNG. Conclusion:The use of mifepristone was simple, and can effectively prevent undesired pregnancy with few side effects.