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糖尿病大鼠组织的蛋白酪氨酸磷酸酶活性变化 被引量：1

Alteration of Protein Phosphotyrosine Phosphatase Activity in Tissues of Diabetic Rats
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摘要 目的:研究蛋白酪氨酸磷酸酶(PTPase)与胰岛素抵抗的关系。方法:链脲佐菌素(STZ)诱发大鼠糖尿病,ELISA法测定糖尿病大鼠各组织器官的PTPase活性,并与正常大鼠进行比较。结果:STZ-糖尿病大鼠肝脏和骨骼肌的PTPase活性升高分别为78%和50%。结论:胰岛素靶细胞的PTPase活性变化与胰岛素抵抗的病因密切相关。 Objective:To study the relation between protein phosphotyrosine phosphatase(PTPase)and insulin resistance. Meth-ods:PTPase activities were measured from streptozotocin(STZ)-induced diabetic rat and normal rat tissues using ELISA. Results:PTPase activities increased by 78% and 50% in liver and skeletal muscle of STZ-induced diabetic rats respectively. Conclusion:Changes of PTPase activities in insulin target tissues will be related to the cause of insulin resistance.
作者 朱宁 田恩江 汤新之
机构地区 天津医科大学生化教研室 天津市内分泌研究所
出处 《天津医药》 CAS 2000年第10期610-611,共2页 Tianjin Medical Journal
基金 天津市自然科学基金
关键词 糖尿病 蛋白酪氨酸磷酸酶 链脲菌素 streptozocin diabetes mellitus, experimental rats protein-tyrosine-phosphatase enzyme-linked im- munosorbent assay insulin resistance
分类号 R587.1 [医药卫生—内分泌]
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参考文献3

  • 1朱宁，天津医药，2000年，28卷，93页
  • 2朱宁，中华内分泌代谢杂志，1998年，14卷，373页
  • 3朱愉，实验动物的疾病模型，1997年，255页

同被引文献22

  • 1Malamas M S. New aolidinediones as inhibitors of protein tyrosine phosphatase 1B with antihyperglycemic properties[J]. J Med Chem, 2000, 43(5):995-1010.
  • 2Asante-Appiah E, Patel S, Dufresne C, et al. The structure of PTP-1B in complex with a peptide inhibitor reveals an alternative binding mode for bisphosphonates[J]. Biochemistry, 2002, 41(29):9043-9051.
  • 3Bleasdale J E, Ogg D, Palazuk B J, et al. Small molecule peptidomimetics containing a novel phosphotyrosine bioisostere ingibit protein tyrosine phosphatase 1B and augment insulin action[J]. Biochemistry,2001,40(19):642- 5654.
  • 4Malamas M S, Sredy J, Moxham C, et al. Novel benzofuran and benzothiophene biphenyls as inhibitors of protein tyrosine phosphatase 1B with antihyperglycemic properties[J]. J Med Chem,2000,43(7):1293-1310.
  • 5Chen H, Cong L N, Li Y, et al. A phosphotyrosyl mimetic peptide reverses impairment of insulin-stimulated translocation of GLUT4 caused by overexpression of PTP1B in rat adipose cell[J]. Biochemistry, 1999,38(1):384-389.
  • 6Chen Y T, Seto C T. Divalent and trivalent alpha-ketocarboxylic acids as inhibitors of protein tyrosine phosphatases[J]. J Med Chem, 2002, 45(18):3946-3952.
  • 7Lima M H, Zambelli J E, Carvalho C R, et al. The insulin receptor substrate 1 associates with phosphotyrosine phosphatase SHPTP2 in liver and muscle of rats[J]. Braz J Med Biol Res. 1998, 31(11):1409-1413.
  • 8Mok A, Cao H, Zinman B, et al. A single nucleotide polymorphism in protein tyrosine phosphatase PTP-1B is associated with protection from diabetes or impaired glucose toleranse in Oji-Gree[J]. J Clin Endocrinol Metab, 2002, 87(2):724-727.
  • 9Asante-Appiah E, Kennedy B P. protein tyrosine phosphatases: the quest for negative regulators of insulin action[J]. Am J Physiol Endocrinol Metab, 2003, 284(4):E663-670.
  • 10Tagami S, Honda T, Yoshimura H, et al. Troglitazone ameliorates abnormal activity of protein tyrosine phosphatase in adipose tissues of Otsuka Long-Evans Tokushima Fatty rats[J]. Exp Med, 2002, 197(3):169-181.

引证文献1

天津医药
2000年 第10期

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