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依达拉奉后处理联合远隔缺血后处理对大鼠心肌缺血再灌注损伤的影响 被引量：6

Effects of edaravone postconditioning and remote ischemic postconditioning on myocardial ischemia/reperfusion injury in rats
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摘要 目的评价依达拉奉后处理联合远隔缺血后处理对大鼠心肌缺血再灌注损伤的影响。方法健康雄性SD大鼠40只，8周龄，体重250～300g，采用随机数字表法，将其分为5组（n=8）：假手术组（S组）、缺血再灌注组（I／R组）、依达拉奉后处理组（E组）、远隔缺血后处理组（P组）、依达拉奉联合远隔缺血后处理组（EP组）。采用结扎左冠状动脉前降支30min，再灌注180min制备心肌缺血再灌注模型。E组和EP组再灌注前1rain静脉注射依达拉奉3mg／kg；P组和EP组左冠状动脉结扎20min时实施远隔后处理：用止血带结扎大鼠双后肢，持续10min。于心肌缺血再灌注期间记录左心室峰压（LVSP）、左心室舒张末压（LVEDP）、左室内压最大上升速率（＋dp／dtmax）、左室内压最大下降速率（-dp／dtmax）。结果与S组比较，其它各组再灌注期间LVSP、＋dp／dtmax、-dp／dtmax降低，LVEDP升高（P〈0．05）；与I／R组比较，E组、P组及EP组再灌注期间LVSP、＋dp／dtmax、-dp／dtmax升高，LVEDP降低（P〈0．05）；与E组和P组比较，EP组再灌注期间LVSP、＋dp／dtmax、-dp／dtmax升高，LVEDP降低（P〈0．05）。结论依达拉奉后处理联合远隔缺血后处理可减轻心肌缺血再灌注损伤，且效果强于两者单独应用。 Objective To evaluate the effects of edaravone postconditioning and remote ischemic postconditioning on myocardial ischemia/reperfusion （I/R） injury in rats. Methods Forty male Sprague-Dawley rats, aged 8 weeks, weighing 250-300 g, were randomly divided into 5 groups （ n = 8 each） ： sham operation group （group S）; group I/R; edaravone postconditioning group （group E）; remote ischemic postconditioning group （group P）; edaravone postconditioning and remote isehemic postconditioning group （group EP）. Myocardial I/R was induced by occlusion of anterior desending branch of left coronary artery for 30 rain followed by 180 rain reper- fusion. Edaravone 3 mg/kg was injected intravenously at 1 min before reperfusion in groups E and EP. The animals underwent 10 min ischemia of bilateral hind limbs starting from 20 rain of myocardial ischemia in groups P and EP. Left ventricular systolic pressure （LVSP）, left ventricular end-diastolic pressure （LVEDP） and ± dp/dtmax, were measured and recorded during reperfusion. Results Compared with group S, LVSP and ± dp/dtmax were significantly decreased and LVEDP was increased in the other groups （P 〈 0.05）. LVSP and ± dp/dtmax were signifi- cantly higher and LVEDP was lower during reperfusion in groups E, P and EP than in group I/R, and in group EP than in groups E and P （P 〈 0.05）. Conclusion Edaravone postconditioning and remote ischemic postconditioning can alleviate myocardial I/R injury and offers better efficacy than either alone.
作者 李恒昌 许立新 李知平 张曙 索琨 佘守章 付晓东
机构地区 广州市第一人民医院麻醉科 广东省东莞市人民医院麻醉科 中山大学生理学教研室
出处 《中华麻醉学杂志》 CAS CSCD 北大核心 2013年第1期99-102,共4页 Chinese Journal of Anesthesiology
基金 广州市医药卫生科技项目（201102A213081） 广东省医学科研基金项目（A2012786）
关键词 自由基清除剂 心肌再灌注损伤 缺血后处理 Free radical scavengers Myocardial reperfusion injury lschemic postconditioning
分类号 R743.3 [医药卫生—神经病学与精神病学]
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参考文献10

  • 1Ivanes F, Rioufol G, Piot C, et al. Postconditioning in acute myo- cardial infarction patients. Antioxid Redox Signal, 2011,14(5) :811- 820.
  • 2Zhou Y, Chen D, Ma Xp,et al. Posteonditioning in cardiopulmouary resuscitation : a better protocol for eardiopulmonary resuscitation. Med Hypotheses, 2009,73 (3) : 321-323.
  • 3Tsujita K, Shimomura H, Kaikita K, et al. Effects of edaravone on reperfusion injury in patients with acute myocardial infarction. Am J Cardiol, 2004, 94 (4):481-484.
  • 4Xin P, Zhu W, Li J, et al. Combined local ischemic postconditioning and remote perconditioning recapitulate cardioproteetive effects of lo- cal ischemic preconditioning. Am J Physiol Heart Cite Physiol, 2010, 298(6) : 1819-1831.
  • 5Vessey DA, Li L, Kelley M, et al. Combined sphingosine, S1P and ischemic postconditioning rescue the heart after protracted ischemia. Bioehem Biophys Res Commun,2008,375(3):425-429.
  • 6Gritsopoulos G, lliodromitis EK, Zoga A, et al. Remote postcondi- tioning is more potent than classic posteonditioning in reducing the in- farct size in anesthetized rabbits. Cardiovasc Drugs Ther, 2009, 23 (3) : 193-198.
  • 7Chimenti S, CarloE, Masson S, et al. Myocardial infarction: animal m- odels. Methods Mol Med, 200d-, 98 : 217-226.
  • 8Zatta AJ,Kin H, Lee G, et al. Infarct-sparing effect of myocardialpostconditioning is dependent on protein kinase C signalling. Cardio- vasc Res,2006, 70(2) :315-324.
  • 9王禹,张永明,刘秀华,张大为,姚树桐.依达拉奉药物后处理与缺血后处理对急性缺血再灌注心肌保护作用的对比实验研究[J].中国循环杂志,2008,23(5):388-391. 被引量：9
  • 10李春梅,张兴华,马晓静,罗曼,刘旭杰,王国栋.远隔预处理和后处理对兔急性心肌缺血再灌注损伤的作用[J].中国老年学杂志,2006,26(9):1239-1241. 被引量：6

二级参考文献29

  • 1刘秀华,唐朝枢.缺血再灌注损伤的防治——从实验室到临床[J].中华心血管病杂志,2006,34(8):677-679. 被引量：33
  • 2赵秀梅,孙胜,刘秀华.垫扎球囊法复制大鼠在体心肌缺血/再灌注模型[J].中国微循环,2007,11(3):206-208. 被引量：45
  • 3Zhao ZQ, Corvera JS, Halkos ME, et al. Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning. Am J Physiol ( Heart Circ Physiol), 2003, 285 (2) :579-588.
  • 4Kloner RA, Rezkalla SH. Preconditioning, postconditioning and their application to clinical cardiology. Cardiovascular Research, 2006,70: 297 -307.
  • 5Vinten-Johansen J, Zhao ZQ, Zatta A J, et al. Postconditioning a new link in nature' s armor against myocardial ischemia-reperfusion injury. Basic Res Cardiol,2005, 100 : 295-310.
  • 6Zhao ZQ, Vinten-Johansen J. Postconditioning: Reduction of reperfu- sion-induced injury. Cariovasc Res ,2006,70:200-211.
  • 7Staat P, Rioufol G, Piot C, et al. Postconditioning the human heart. Circulation ,2005,112 ( 14 ) :2143-2148.
  • 8Higashi Y, Jitsuiki D, Chayama K, et al. Edaravone, a Novel free radical scavenger, for treatment of cardiovascular diseases. Recent Patents Cardiovasc Drug Discov, 2006, 1 : 85-93.
  • 9Kin H, Zhao ZQ, Sun HY, et al. Postconditioning attenuates myocardial ischemia reperfusion injury by inhibiting events in the early minutes of reperfusion. Cardiovasc Res ,2004,62 ( 1 ) :74-85.
  • 10Sun HY, Wang NP, Halkos M, et al. Postconditioning attenuates cardiomyocyte apoptosis via inhibition of JNK and p38 mitogen-activated protein kinase signaling pathways. Apoptosis ,2006, 11 : 1583-1593.

共引文献13

同被引文献55

  • 1李春梅,张兴华,马晓静,罗曼,刘旭杰,王国栋.肢体缺血后处理对兔急性心肌缺血再灌注损伤的影响[J].中国病理生理杂志,2006,22(12):2332-2335. 被引量：18
  • 2Vollmar B, Menger M D. Intestinal ischemia/reperfusion : microcir- culatory pathology and functional consequences [ J ]. Langenbecks Arch Surg,2011,396( 1 ) : 13-29.
  • 3Mallick I H, Yang W X, Winslet M C, et al. Ischemia-reperfusi0n injury of the intestine and protective strategies against injury [ J ]. Dig Dis Sci,2004,49(9) :1359-1377.
  • 4Fukuda K, Asoh S, Ishikawa M, et al. Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress [ J ]. Biochem Biophys Res Commun,2007, 361 ( B ) :670-674.
  • 5Mao Y F,Zheng X F, Cai J M,et al. Hydrogen-rich saline reduces lung injury induced by intestinal ischemia/reperlusion in rats[ J]. Biochem Biophys Res Commun,2009 ,381 (4) :602-605.
  • 6Chiu C J, Mc Ardle A H, Brown R, et al. Intestinal mucosal lesion in low-flow states. I. A morphological, hemodynamic, and metabolic reappraisal [ J ]. Arch Surg, 1970,101 (4) :478-483.
  • 7Ohsawa I ,Ishikawa M ,Takahashi K,et al. Hydrogen acts as a ther- apeutic antioxidant by selectively reducing cytotoxic oxygen radi- cals[ J]. Nat Med,2007,13(6) :688-694.
  • 8Zhao Z Q, Corvera J S, Halkos M E, et al. Inhibition of myocardial injury by ischemic postconditioning during reperfusion:comparison with ischemic preconditioning[ J]. Am J Physiol Heart Circ Physi- ol,2003,285 (2) :H579-588.
  • 9Leng Y F,Zhang Y,Zhang Y,et al. Isehemic post-conditioning at- tenuates the intestinal injury induced by limb isehemia/reperfa- sion in rats [ J ]. Braz J Med Biol Res, 2011,44 ( 5 ) :411-417.
  • 10Xin P, Zhu W, Li J, et al. Combined local ischemic postcondition- ing and remote percondigoning recapitulate cardioproteetive effects of local ischemic preconditioning [ J ]. Am J Physiol Heart Circ Physiol,2010 ,298( 6 ) :1819-1831.

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二级引证文献18

中华麻醉学杂志
2013年 第1期

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