红棕杜鹃(原变种)叶的化学成分研究

Chemical constituents from leaves of Rhododendron rubiginosum var.rubiginosum

利用各种色谱技术对红棕杜鹃(原变种)Rhododendron rubiginosum var.rubiginosum叶进行化学成分研究。从中分离得13个化合物,并通过理化性质与波谱分别鉴定为3,9-dihydroxy-megastigma-5-ene(1),3β-hydroxy-5α,6α-epoxy-7-me-gastigmen-9-one(2),黑麦草内酯(3),熊果酸(4),2α,3β-二羟基乌苏-12-烯-28-酸(5),2α,3β,23-三羟基乌苏-12-烯-28-酸(6),7,9-二甲氧基杜鹃醇(7),7-甲氧基杜鹃醇(8),姜酮(9),异嗪皮啶(10),东莨菪内酯(11),(+)-松脂素(12),3'-O-去甲基表松脂素(13)。化合物1～13均首次从本种分离得到,其中化合物1～3,7～9,11～13首次从本属分离得到。

Thirteen compounds were isolated from the leaves of Rhododendron rubiginosum var. rubiginosum by various chromatographic techniques. On the basis of spectroscopic data, their structures were elucidated as 3,9-dihydroxy-megastigma-5-ene （ 1 ）, 3β-hydroxy-Sa, 6a-epoxy-7-megastigmen-9-one （2）, loliolide （ 3 ）, ursolic acid （ 4 ）, 2a, 3β-dihydroxy-urs-12-en-28-oic acid （ 5 ）, 2a, 3,8,23-trihydroxy-urs- 12 -en-28-oic acid （6）, 7,9 -dimethoxyrhododendrol （7）, 7-methoxyrhododendrol （ 8 ）, zingerone （ 9 ）, isofraxidin （10）, scopoletin （ 11）, （ ＋ ） -pinoresinol （12） and 3＇-O-demethylepipinorisenol （13）. All compounds were isolated from this plant for the first time, and compounds 1-3, 7-9, and 11-13 were isolated from the genus Rhododendron for the first time.